Results 91 to 100 of about 666,264 (255)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Poverty and Iinequality Sstudies in Iran A Book Rreview of “The Necessity of Fighting the Poverty and Inequality in Iran” [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2019 Poverty and inequality in Iran are two important phenomena the depth and breadth of which have attracted the attention of social and economic thinkers and have been studied from various perspectives.
Mohamad Farhadi
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Using rights-based approaches to tackle poverty: funded intitatives 2005
, 2006 Combat Poverty Agency believes that tackling poverty involv'es the recognition of economic, social and cultural rights, the eradication of discrimination and respect for diversity.
Combat Poverty Agency
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Social Work and Society, 2019 We are currently witnessing a shift in the public response to poverty within our societies. The establishment and consolidation of food banks in Germany and in many other western European countries change the character of the welfare state.
Holger Schoneville
doaj +2 more sources
Revista Tempo do MundoBrazil's Presidency in the G20 in 2024 marks a turning point by proposing an integrated approach to address the interconnected challenges of combating hunger, climate change, and promoting bioeconomy.
Júlia Mascarello Fundação +2 more
doaj +1 more source
POVERTY, POLICY AND PLACE: HOW POVERTY AND POLICIES TO ALLEVIATE POVERTY ARE SHAPED BY LOCAL CHARACTERISTICS [PDF]
Food Security and Poverty,
Blank, Rebecca M.
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