Results 81 to 90 of about 666,264 (255)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Orphanhood, Poverty and the Care Dilemma: Review of Global Policy Trends
Social Work and Society, 2009 The care and protection of children experiencing orphanhood presents a major child-care policy challenge. This paper draws on a review of the literature to document divergent conceptualizations of orphanhood, how the hurdles for the care of orphans ...
Tatek Abebe
doaj +2 more sources
EFFECTS OF REMITTANCES ON POVERTY REDUCTION: THE CASE OF INDONESIA
Journal of Indonesian Economy and Business, 2017 Remittances have been reported as a tool for fighting poverty in some selected countries, such as Indonesia. An increase of income through remittances tends to improve the economic status of the migrant’s household. Once they get a high salary, they will
Faiza Husnayeni Nahar +1 more
doaj +1 more source
People, poverty & participation
, 2009 The policy discussion paper is structured in four chapters: • Chapter 2 briefly discusses the relationship between participative and representative democracy. It also describes a number of participation models.
Combat Poverty Agency (CPA)
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
An exploration of perceptions on poverty: The case of the Methodist Church of Southern Africa at Alice Region Eastern Cape – A qualitative approach. [PDF]
Pharos Journal of Theology, 2018 This paper sought to explore the perceptions of and the experiences of Methodist Church of Southern Africa (MCSA) Alice Region in alleviating poverty. The study from which this paper is derived, was informed by a qualitative approach using a case study ...
X. T. Jibiliza (PhD Candidate) +1 more
doaj
Consumption and Income Poverty over the Business Cycle [PDF]
We examine the relationship between the business cycle and poverty for the period from 1960 to 2008 using income data from the Current Population Survey and consumption data from the Consumer Expenditure Survey.
Bruce D. Meyer, James X. Sullivan
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A poverty profile of the Western Cape province of South Africa. [PDF]
Poverty reduction and alleviation is a main priority of the South African government. For the Western Cape province to formulate and implement successful, well-targeted policies aimed at reducing poverty it is important to identify exactly who the poor ...
Liezl Nieuwoudt, Morné Oosthuizen
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