Results 71 to 80 of about 12,963 (306)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
THE ROLE OF SOCIAL CAPITAL AND INTERPERSONAL RELATIONS IN THE ALLEVIATION OF EXTREME POVERTY AND SPATIAL SEGREGATION OF ROMANI PEOPLE IN SZEGED [PDF]
Journal of Urban and Regional Analysis, 2017 Even more emphasis is set on social capital in understanding, analyzing and planning poverty alleviation measures and policies. However, our understanding of the role of social capital in alleviating extreme poverty, enhancing social mobility and ...
Boglárka MÉREINÉ BERKI +3 more
doaj
L’intégration des cueilleurs de déchets latino-américains ou la création d’une nouvelle marge
EchoGéo, 2019 For decades, Latin American cities have been fighting against informal wastepickers, prioritizing sanitary safety and hygienist logic. Today, struggles against the waste of resources and against poverty lead recognition of wastepickers activities. These "
Mathieu Durand +1 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Orphanhood, Poverty and the Care Dilemma: Review of Global Policy Trends
Social Work and Society, 2009 The care and protection of children experiencing orphanhood presents a major child-care policy challenge. This paper draws on a review of the literature to document divergent conceptualizations of orphanhood, how the hurdles for the care of orphans ...
Tatek Abebe
doaj +2 more sources
POVERTY, POLICY AND PLACE: HOW POVERTY AND POLICIES TO ALLEVIATE POVERTY ARE SHAPED BY LOCAL CHARACTERISTICS [PDF]
Food Security and Poverty,
Blank, Rebecca M.
core +1 more source
Half Measures: The ANC's Unemployment and Poverty Reduction Goals [PDF]
, 2004 Simulations suggest that under the most optimistic conditions, halving the official rate of unemployment would require 3.7 million jobs to be created between 2004 and 2014. Halving the number of expanded unemployed under pessimistic assumptions about the
Meth, Charles
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Institutional Framework and Poverty: A Transition Economy Perspective [PDF]
This paper focuses on the role of institutions in poverty alleviation, where both poverty and institutions are interpreted broadly. The broadening of the poverty notion is important at least from the policy perspective.
Syed M. Ahsan
core +3 more sources