Results 41 to 50 of about 666,264 (255)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fighting poverty, inequality and injustice
, 2011 Fighting poverty, inequality and ...
Adrian Sinfield (17246590) +2 more
core +5 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
SAGE Open, 2019 As an effective means in fighting poverty, microfinance experienced an unprecedented growth in many emerging economies followed by stagnation and deep crisis, due to an inherent paradox in the fundamental missions of microfinance industry: serving the ...
Jiguang Wang, Bing Ran
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The role of islamic finance in fighting poverty
المجلة الدولية للأداء الاقتصادي, 2018 The study aims to extend and further the current literature related to the inclusion of Islamic finance in the international strategies that have been established against poverty. The study shows that despite the fact that poverty is a worldwide problem,
Lynda OUENDI, Abdelmadjid Ounis
doaj
Understanding and Fighting Poverty – Amartya Sen’s Capability Approach and Related Theories
Social Change Review, 2012 This article scrutinises the usefulness of Sen’s capability approach and other related theories for understanding poverty and traceability of social-welfare interventions. In addition to the capability approach three macro level approaches are discussed:
Knech Alban
doaj +1 more source
Spatial zoning and spatial analysis of urban poverty using spatial analysis (Case study: Mashhad city) [PDF]
تحقیقات کاربردی علوم جغرافیایی, 2021 Spatial Zoning and Analysis of Urban Poverty via Spatial Analysis (Case Study: Mashhad City) Abstract Examining the degree of poverty in every community is the first step taken towards planning for fighting against poverty and deprivation.
Hadi Soleimani moghadam +2 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source