Results 41 to 50 of about 12,963 (306)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
SAGE Open, 2019 As an effective means in fighting poverty, microfinance experienced an unprecedented growth in many emerging economies followed by stagnation and deep crisis, due to an inherent paradox in the fundamental missions of microfinance industry: serving the ...
Jiguang Wang, Bing Ran
doaj +1 more source
THE ROLE OF RURAL DEVELOPMENT IN FIGHTING POVERTY IN IRAQ FOR THE PERIOD 1980-2005 [PDF]
Mesopotamia Journal of Agriculture, 2009 Poverty is considered a complicated phenomenon which has serious social, political and economic dimensions. Poverty scope is unlimited by a certain geographic region or a certain period of time.
Aswan Abdul-Kadir Zaydan
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Understanding and Fighting Poverty – Amartya Sen’s Capability Approach and Related Theories
Social Change Review, 2012 This article scrutinises the usefulness of Sen’s capability approach and other related theories for understanding poverty and traceability of social-welfare interventions. In addition to the capability approach three macro level approaches are discussed:
Knech Alban
doaj +1 more source
Spatial zoning and spatial analysis of urban poverty using spatial analysis (Case study: Mashhad city) [PDF]
تحقیقات کاربردی علوم جغرافیایی, 2021 Spatial Zoning and Analysis of Urban Poverty via Spatial Analysis (Case Study: Mashhad City) Abstract Examining the degree of poverty in every community is the first step taken towards planning for fighting against poverty and deprivation.
Hadi Soleimani moghadam +2 more
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Food security and COVID-19 in Afghanistan: a two-sided battlefront
Tropical Medicine and Health, 2021 Food security is a major element for the sustainability, stability and development of a country. However, despite fundamental efforts in fighting poverty, Afghanistan continues to struggle with food insecurity with a large proportion of its population ...
Attaullah Ahmadi +10 more
doaj +1 more source