Results 151 to 160 of about 21,508 (266)

Summary of single nucleotide polymorphisms in filaggrin associated with atopic dermatitis

JEADV Clinical Practice
Background Loss of function mutations in the filaggrin gene (FLG) play an important role in the pathogenesis of atopic dermatitis (AD). However, FLG is structurally challenging to sequence using conventional high‐throughput techniques.
Rachita Pandya, Mohsen Baghchechi, Sinead Langan, David J. Margolis, Lavinia Paternoster, Cathryn Sibbald, Joy Wan, Saman Zaman, Katrina Abuabara   +8 more
doaj   +1 more source

Clinical and Molecular Effect of the Anti–IL‐18 Antibody Aletekitug in Adults With Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 539-551, February 2026.
At Week 12, aletekitug was associated with a −68.3% percentage change from baseline in EASI score. Aletekitug improved the transcriptional profile of lesional skin towards that of non‐lesional skin at Week 4 and Week 12. Aletekitug was well‐tolerated; no serious adverse event or death occurred, and no patient withdrew due to an adverse event.
Joanne Ellis, Léa Fortunato, Hannah Wajdner, Ester Del Duca, Joanna Barnard, Joanna C. Betts, Swaroop Bose, John Browning, Núria Buil‐Bruna, Scott Van Buren, Eden David, Scott Dinehart, Puneet Dhawan, Yeriel Estrada, Parima Ghafoori, Kiranmai Gumireddy, Zhenghong Li, Wei Jing Loo, Fiona Lovegrove, Jenny Lowe, Lawrence Charles Parish, Will Powley, Naveen Prasad, Joel Correa Da Rosa, Marieta Ruseva, Neda Shokrian, Farhat Syed, Chun‐Hang Tang, Gabriel K. Wong, John B. Kelly, Nicolas Wisniacki, Iain Uings, Emma Guttman‐Yassky   +32 more
wiley   +1 more source

Pathogenic Variants in Mennonites From Southern Brazil: Implications for Preventive Measures in Public Health

Clinical Genetics, Volume 109, Issue 2, Page 266-276, February 2026.
In 325 exomes of South Brazilian Mennonites, we identified 23 pathogenic variants (P) and 27 likely P, with founder effects identified for 96% of P, whose frequencies differed from non‐Finnish Europeans, Amish, and Brazilian populations. ABSTRACT The Mennonite population has a unique history of 500 years of genetic isolation shaped by at least three ...
Luiza Beatriz Mayer de Lima, Eduardo Delabio Auer, Isabela Dall’Oglio Bucco, Valéria Bumiller‐Bini Hoch, Priscila Ianzen dos Santos, Fabiana L. Lopes, Alan Shuldiner, Emilton Lima Júnior, Angelica Beate Winter Boldt   +8 more
wiley   +1 more source

Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Function

Acta Dermato-Venereologica, 2017
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Corticosteroids, which are widely used for AD treatment, have adverse effects, and alternative treatments are urgently needed.
Kiyoko Yamada, Kenji Matsushita, Jingshu Wang, Takuro Kanekura   +3 more
doaj   +1 more source

Deiminált fehérjeantigének szerepének vizsgálata a rheumatoid arthritis patomechanizmusában és diagnosztikájában = Study of the role of deiminated protein antigens in the pathomechanism and diagnosis of rheumatoid arthritis [PDF]

, 2007
Eredmények: 1. Szintetikus peptidekkel igazoltuk, hogy a citrullin nélkülözhetetlen az anti-filaggrin típusú , rheumatoid arthritisre (RA) specifikus antitestek által felismert epitópok szerkezetében.
Brózikné Horváth, Márta, Gergely, Péter, Hudecz, Ferenc, Magyar, Anna, Merétey, Katalin, Palkonyai, Éva, Szakonyi, József   +6 more
core  

Evaluation of the sensitive skin syndrome and the effect of a dermo‐cosmetic treatment in Thai and Polish subjects

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 70-82, February 2026.
Sensitive skin assessment in Thai and Polish subjects showed a dermo‐cosmetic product improved symptoms and quality of life in both groups, also highlighting ethnic differences in syndrome perception at baseline. Abstract Objective Sensitive skin syndrome (SSS) affects individuals from all ethnic groups.
Helena Polena, Sylwia Czaińska, Benoît Cadars, Ewa Chlebus, Monika Serafin, Waranya Boonchai, Pichanee Chaweekulrat, Silada Kanokrungsee, Marlène Chavagnac‐Bonneville, Christelle Graizeau, Michèle Sayag, Elodie Prestat‐Marquis   +11 more
wiley   +1 more source

Variation in the activities of late stage filaggrin processing enzymes, calpain-1 and bleomycin hydrolase, together with pyrrolidone carboxylic acid levels, corneocyte phenotypes and plasmin activities in non-sun-exposed and sun-exposed facial stratum corneum of different ethnicities [PDF]

, 2016
BACKGROUND: Knowledge of the ethnic differences and effects of photodamage on the relative amounts of natural moisturizing factor (NMF) together with filaggrin processing enzymes in facial stratum corneum is limited.
Lane, ME, Munday, MR, Raj, N, Rawlings, AV, Summers, B, Voegeli, R   +5 more
core  

Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.

Journal of Allergy and Clinical Immunology, 2021
Christopher H. Arehart, M. Daya, Monica Campbell, M. Boorgula, N. Rafaels, S. Chavan, G. David, J. Hanifin, M. Slifka, R. Gallo, T. Hata, L. Schneider, A. Paller, P. Ong, J. Spergel, E. Guttman‐Yassky, D. Leung, L. Beck, Christopher R. Gignoux, R. Mathias, K. Barnes   +20 more
semanticscholar   +1 more source

Incidence Rate of Otitis Externa Episodes in Atopic Dogs Is Reduced by a Therapeutic Diet in a 6‐Month Randomised, Blinded, Controlled, Clinical Trial

Veterinary Dermatology, Volume 37, Issue 1, Page 89-102, February 2026.
ABSTRACT Background Recurrent otitis externa (OE) episodes commonly affect dogs with canine atopic dermatitis (cAD) despite ongoing cAD treatment. Objective To determine if a therapeutic diet with active ingredients targeting the skin barrier and allergy pathways reduces the incidence rate of OE.
Adrian Watson, Jeremy Laxalde, Franco Martini, Nina Fischer, Elisa Maina, Claude Favrot   +5 more
wiley   +1 more source

Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation

Acta Dermato-Venereologica
The World Allergy Organization recommends probiotics in the prevention of atopic dermatitis in high-risk populations. Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermatitis through disruption of the skin keratin layer ...
Dinastry Pramadita Zakiudin, Jacob P. Thyssen, Claus Zachariae, Vibeke Videm, Torbjørn Øien, Melanie Rae Simpson   +5 more
doaj   +1 more source