Results 221 to 230 of about 21,508 (266)
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Skin barrier dysfunction and filaggrin
Archives of Pharmacal Research, 2021Skin barrier dysfunction caused by endogenous or exogenous factors can lead to various disorders such as xerosis cutis, ichthyoses, and atopic dermatitis. Filaggrin is a pivotal structural protein of the stratum corneum (SC) and provides natural moisturizing factors that play a role in skin barrier functions.
Yeonjoon Kim, Kyung-Min Lim
semanticscholar +3 more sources
Atopic dermatitis: filaggrin and skin barrier dysfunction
British Journal of Dermatology, 2022Atopic dermatitis (AD) is among the most common skin diseases that affect children and adults. It has been associated with several other atopic illnesses like asthma, seasonal allergies and food allergies and is often considered to be the first illness ...
D. Margolis
semanticscholar +1 more source
Journal of dermatology (Print), 2022
Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD). AD skin‐derived strains of S. aureus (AD strain) are selectively internalized into keratinocytes (HaCaT cells) compared to standard strains ...
R. Miyake +8 more
semanticscholar +1 more source
Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD). AD skin‐derived strains of S. aureus (AD strain) are selectively internalized into keratinocytes (HaCaT cells) compared to standard strains ...
R. Miyake +8 more
semanticscholar +1 more source
International Journal of Dermatology, 2021
Filaggrin (FLG) loss‐of‐function variants are major genetic risk factors for atopic dermatitis (AD), but these have not been studied in Latin American populations with and without AD.
G. Cárdenas +14 more
semanticscholar +1 more source
Filaggrin (FLG) loss‐of‐function variants are major genetic risk factors for atopic dermatitis (AD), but these have not been studied in Latin American populations with and without AD.
G. Cárdenas +14 more
semanticscholar +1 more source
Atopic dermatitis and filaggrin
Current Opinion in Immunology, 2016Filaggrin has a key structural and functional role in the epidermis with important impact on the homeostasis of the skin. Inherited or acquired filaggrin deficiency has been described to essentially contribute to the pathogenesis of atopic dermatitis (AD), one of the most frequent chronic eczematous skin diseases in child-hood and adult-hood ...
Beatriz, Cabanillas, Natalija, Novak
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Filaggrin and childhood eczema
Archives of Disease in Childhood, 2017Atopic dermatitis (AD) is an inflammatory skin disease characterised by pruritus, dry skin, crusting and lichenification with a worldwide lifetime prevalence ranging from 1.8% to 44% across different populations.1 This disease poses significant medical, psychosocial and financial burdens for children and their families.2 AD has a complex aetiology that
Margaret Dennin, Peter A Lio
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Filaggrin in atopic dermatitis
Journal of Allergy and Clinical Immunology, 2008The recent identification of loss-of-function mutations in the structural protein filaggrin as a widely replicated major risk factor for eczema sheds new light on disease mechanisms in eczema, a disease that had heretofore largely been considered to have a primarily immunologic etiopathogenesis. The filaggrin gene (FLG) mutation findings are consistent
O'Regan, Grainne M. +3 more
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Journal of the European Academy of Dermatology and Venereology, 2020
FLG loss‐of‐function mutations (FLG LOF) represent the strongest genetic risk factor for atopic dermatitis (AD) and are associated with early‐onset and more severe disease. The prevalence of FLG mutations varies greatly across Europe.
R. Jurakic Toncic +8 more
semanticscholar +1 more source
FLG loss‐of‐function mutations (FLG LOF) represent the strongest genetic risk factor for atopic dermatitis (AD) and are associated with early‐onset and more severe disease. The prevalence of FLG mutations varies greatly across Europe.
R. Jurakic Toncic +8 more
semanticscholar +1 more source
1999
Abstract Filaggrin is named for its ability to cause intermediate filament aggregation in vitro. It is one of the original proteins recognized as an ‘intermediate filament-associated protein’ or IFAP. Filaggrin is expressed by keratinocytes of epidermis and other cornified epithelia as the cells undergo terminal differentiation and form ...
Beverly A Dale, Richard B Presland
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Abstract Filaggrin is named for its ability to cause intermediate filament aggregation in vitro. It is one of the original proteins recognized as an ‘intermediate filament-associated protein’ or IFAP. Filaggrin is expressed by keratinocytes of epidermis and other cornified epithelia as the cells undergo terminal differentiation and form ...
Beverly A Dale, Richard B Presland
openaire +1 more source