Results 241 to 250 of about 21,508 (266)

Atopic Eczema and the Filaggrin Story

Seminars in Cutaneous Medicine and Surgery, 2008
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema represents the single most significant breakthrough in understanding the genetic basis of this complex disorder. The association has been replicated in multiple independent studies during the past 2 years with the use of various methodologies, from ...
Brown, Sara J., Irvine, Alan D.
openaire   +3 more sources

Filaggrin gene mutations in relation to contact allergy and hand eczema in adolescence

Contact Dermatitis, 2019
Filaggrin is an important protein for structure and function of the skin barrier. Filaggrin gene (FLG) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis.
M. Lagrelius, C. Wahlgren, M. Bradley, E. Mélen, I. Kull, A. Bergström, C. Lidén   +6 more
semanticscholar   +1 more source

Filaggrin in Psoriasis

2014
Psoriasis is a chronic inflammatory skin disease of multifactorial origin. A number of psoriasis susceptibility loci are known, and some are shared with susceptibility for atopic dermatitis. This has led to speculation that filaggrin gene (FLG) mutations and changes in filaggrin expression may also be associated with psoriasis.
Peter Jensen, Lone Skov
openaire   +1 more source

Latex allergy and filaggrin null mutations

Journal of Dentistry, 2011
Natural rubber latex (NRL) contains over 200 proteins of which 13 have been identified as allergens and the cause of type I latex allergy. Health care workers share a high occupational risk for developing latex allergy. Filaggrin null mutations increase the risk of type I sensitizations to aeroallergens and it is possible that filaggrin null mutations ...
Carlsen, Berit C, Meldgaard, Michael, Hamann, Dathan, Hamann, Quinlan, Hamann, Carsten, Thyssen, Jacob P, Meyer, Daniel M, Gruninger, Stephen E, Hamann, Curt   +8 more
openaire   +3 more sources

Filaggrin and Skin Infections

2014
The skin forms an important physical and immune barrier against microbes. Filaggrin, one of the key components of the stratum corneum, is now increasingly known to be the driving force in a wide range of metabolic, immune, and inflammatory processes of the skin barrier.
Emily Y. Gan, Sophie C. S. Cai, Mark B. Y. Tang   +2 more
openaire   +1 more source

The Eye and Filaggrin

2014
The role of filaggrin in ophthalmology has only been investigated recently. This chapter provides an overview of the literature on this area and outlines the authors’ detection of filaggrin on parts of the eye that have not yet been analyzed for filaggrin: the lens, the retinal pigment epithelium, and the ciliary body.
Anne Sofie Lund Bateman, Steffen Heegaard   +1 more
openaire   +1 more source

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Nature Genetics, 2006
C. Palmer, A. Irvine, A. Terron-Kwiatkowski, Yiwei Zhao, H. Liao, Simon P. Lee, D. Goudie, A. Sandilands, L. Campbell, F. Smith, G. O’Regan, R. Watson, Joanne E. Cecil, S. Bale, J. Compton, John J. DiGiovanna, John J. DiGiovanna, P. Fleckman, S. Lewis-jones, G. Arseculeratne, A. Sergeant, C. Munro, B. E. Houate, K. McElreavey, L. Halkjaer, H. Bisgaard, Somnath Mukhopadhyay, Somnath Mukhopadhyay, W. McLean   +28 more
semanticscholar   +1 more source

Filaggrin in Canine Skin

2014
Filaggrin is an epidermal protein that contributes to the structure of the cornified envelope. Impaired filaggrin functions, either by filaggrin gene (FLG) mutation or by altered filaggrin expression, may lead to skin disease and enhance antigen penetration.
Gunnaporn Suriyaphol, Sirin Theerawatanasirikul, Prapat Suriyaphol   +2 more
openaire   +1 more source

The Role of Filaggrin in Atopic Dermatitis and Allergic Disease.

Annals of Allergy, Asthma & Immunology, 2019
C. Drislane, A. Irvine
semanticscholar   +1 more source

Pyridoxine stimulates filaggrin production in human epidermal keratinocytes

Molecular Biology Reports, 2021
M. Fujishiro, S. Yahagi, Shota Takemi, Mio Nakahara, T. Sakai, I. Sakata   +5 more
semanticscholar   +1 more source