Results 261 to 270 of about 21,702 (299)
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Skin barrier dysfunction and filaggrin
Archives of Pharmacal Research, 2021Skin barrier dysfunction caused by endogenous or exogenous factors can lead to various disorders such as xerosis cutis, ichthyoses, and atopic dermatitis. Filaggrin is a pivotal structural protein of the stratum corneum (SC) and provides natural moisturizing factors that play a role in skin barrier functions.
Yeonjoon Kim, Kyung-Min Lim
semanticscholar +4 more sources
Atopic dermatitis: filaggrin and skin barrier dysfunction
British Journal of Dermatology, 2022Atopic dermatitis (AD) is among the most common skin diseases that affect children and adults. It has been associated with several other atopic illnesses like asthma, seasonal allergies and food allergies and is often considered to be the first illness ...
D. Margolis
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Journal of dermatology (Print), 2022
Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD). AD skin‐derived strains of S. aureus (AD strain) are selectively internalized into keratinocytes (HaCaT cells) compared to standard strains ...
R. Miyake +8 more
semanticscholar +1 more source
Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD). AD skin‐derived strains of S. aureus (AD strain) are selectively internalized into keratinocytes (HaCaT cells) compared to standard strains ...
R. Miyake +8 more
semanticscholar +1 more source
Atopic dermatitis and filaggrin.
Current Opinion in Immunology, 2016Filaggrin has a key structural and functional role in the epidermis with important impact on the homeostasis of the skin. Inherited or acquired filaggrin deficiency has been described to essentially contribute to the pathogenesis of atopic dermatitis (AD), one of the most frequent chronic eczematous skin diseases in child-hood and adult-hood ...
B. Cabanillas, N. Novak
semanticscholar +4 more sources
Filaggrin in atopic dermatitis
Journal of Allergy and Clinical Immunology, 2008The recent identification of loss-of-function mutations in the structural protein filaggrin as a widely replicated major risk factor for eczema sheds new light on disease mechanisms in eczema, a disease that had heretofore largely been considered to have a primarily immunologic etiopathogenesis. The filaggrin gene (FLG) mutation findings are consistent
W.H. Irwin McLean +4 more
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Filaggrin and childhood eczema
Archives of Disease in Childhood, 2017Atopic dermatitis (AD) is an inflammatory skin disease characterised by pruritus, dry skin, crusting and lichenification with a worldwide lifetime prevalence ranging from 1.8% to 44% across different populations.1 This disease poses significant medical, psychosocial and financial burdens for children and their families.2 AD has a complex aetiology that
Margaret Dennin, Peter A Lio
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Keratin and filaggrin expression in keratoacanthoma
Journal of the European Academy of Dermatology and Venereology, 2007AbstractTo clarify the histogenesis of keratoacanthoma, we studied keratin (K) expression in keratoacanthoma (KA) using 10 different anti‐keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18 and K19 and anti‐filaggrin (filament aggregating protein) antibody.
Keisuke Nishimura +7 more
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Detection of New Epitopes of Antibodies to Filaggrin in Filaggrin Protein Molecule
Bulletin of Experimental Biology and Medicine, 2011Immunogenic characteristics of filaggrin protein molecule as an antigen for antibodies to filaggrin, markers of early rheumatoid arthritis, were studied. Two new peptide motives, possible epitopes for antibodies to filaggrin, were shown in the filaggrin molecule by predictive analysis using programmed algorithms.
M. Yu. Sandin +5 more
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The role of filaggrin in the atopic diathesis
Clinical & Experimental Allergy, 2010SummaryAtopic dermatitis (AD) is an inflammatory disease characterized by pruritic skin lesions, immunodysregulation, disrupted epidermal barrier function and IgE‐mediated sensitization to food and environmental allergens. Identification of the aetiology of AD has become increasingly a priority, as it is clear that the disease burden exceeds AD alone ...
Grainne M. O'Regan +2 more
openaire +3 more sources
Journal of the European Academy of Dermatology and Venereology, 2020
FLG loss‐of‐function mutations (FLG LOF) represent the strongest genetic risk factor for atopic dermatitis (AD) and are associated with early‐onset and more severe disease. The prevalence of FLG mutations varies greatly across Europe.
R. Jurakic Toncic +8 more
semanticscholar +1 more source
FLG loss‐of‐function mutations (FLG LOF) represent the strongest genetic risk factor for atopic dermatitis (AD) and are associated with early‐onset and more severe disease. The prevalence of FLG mutations varies greatly across Europe.
R. Jurakic Toncic +8 more
semanticscholar +1 more source