Results 31 to 40 of about 15,999 (185)

Critical role of keratinocytes and protease‐activated receptor 2 in secondary lymphedema development

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Activated keratinocytes play an important role in the early stage of the pathophysiology of secondary lymphedema through PAR2 signaling. Lymphatic injury‐induced protease activation stimulates keratinocyte PAR2 signaling, driving hyperkeratosis and Th2 inflammation, which can be therapeutically attenuated by teriflunomide. Abstract Background Secondary
Hyeung Ju Park, Sarit Pal, Xizhao Chen, Jinyeon Shin, Gabriela D. García Nores, Jung Eun Baik, Annica Stull‐Lane, Abraham J. Book, Cristina C. Clement, Elizabeth M. Encarnacion, Mark G. Klang, Elyn Riedel, Tafadzwa L. Chaunzwa, Geoffrey E. Hespe, Laura Santambrogio, Michelle Coriddi, Joseph H. Dayan, Babak J. Mehrara, Raghu P. Kataru   +18 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

A Simple Genotyping Method for Rapid Differentiation of Blastocystis Subtypes and Subtype Distribution of Blastocystis spp. in Thailand

Pathogens, 2019
Blastocystis spp. is one of the most common protozoa of humans and animals worldwide. The genetic diversity of Blastocystis spp. might be associated with a wide range of symptoms.
Nittaya Srichaipon, Surang Nuchprayoon, Sarit Charuchaibovorn, Pattadon Sukkapan, Vivornpun Sanprasert   +4 more
doaj   +1 more source

HUBUNGAN SIKAP MASYARAKAT DENGAN KEPATUHAN PENGOBATAN MASSAL FILARIASIS DI KECAMATAN BAKTIYA ACEH UTARA

Averrous: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2020
Filariasis masih menjadi salah satu masalah kesehatan masyarakat di Kabupaten Aceh Utara dan angka kejadian tertinggi tingkat propinsi Aceh. Kecamatan Baktiya paling tinggi angka kejadian di Aceh utara.
Yuziani Yuziani, Mulyati Sri Rahayu
doaj   +1 more source

Filariasis and lymphoedema [PDF]

Parasite Immunology, 2009
SummaryAmong the causes of lymphoedema (LE), secondary LE due to filariasis is the most prevalent. It affects only a minority of the 120 million people infected with the causative organisms of lymphatic filariasis (LF), Wuchereria bancrofti and Brugia malayi/timori, but is clustered in families, indicating a genetic basis for development of this ...
PFARR, K M, DEBRAH, A Y, SPECHT, S, HOERAUF, A   +3 more
openaire   +2 more sources

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Brazil was certified by the World Health Organization for having eliminated lymphatic filariasis: what now?

Parasites & Vectors
Lymphatic filariasis (LF) is a debilitating and stigmatizing disease. In Brazil, the disease has been the target of control and elimination strategies for more than 25 years. Recently, the country received the certificate of elimination of LF as a public
Eduardo Brandão, Paula Oliveira, Maria Almerice Lopes da Silva, Abraham Rocha   +3 more
doaj   +1 more source

An inquiry‐based activity to teach about insects of medico‐legal importance: Lessons from Redi's landmark experiment

Natural Sciences Education, Volume 55, Issue 1, June 2026.
Abstract In this article, we describe an inquiry‐based teaching activity developed in a public high school in Brazil. The objectives were to (a) develop an experimental activity grounded on the students’ autonomy for formulating and testing hypotheses, (b) address Biology topics from a historical and multidisciplinary perspective, (c) stimulate skills ...
Simão Dias Vasconcelos, Paulo Herton Costa   +1 more
wiley   +1 more source

Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice

Journal of Infection in Developing Countries, 2015
Introduction: Different results have been achieved in the evaluation of antiparasitic drug activity in Mongolian jirds, hamsters, and BALB/c mice infected with Babesia microti.
Jun-ming Yao, Hao-bing Zhang, Cong-shan Liu, Yi Tao, Meng Yin   +4 more
doaj   +1 more source

Mitochondrial Genome of Brugia malayi Microfilariae Isolated From a Clinical Sample

Frontiers in Ecology and Evolution, 2021
Lymphatic filariasis is a neglected parasitic disease that is a leading cause of long-term disability. Information obtained from genome sequencing of filarial worm can help us identify systems in the worm that are likely to be useful for novel drug ...
Xiong Qing, Kasem Kulkeaw, Sirichit Wongkamchai, Stephen Kwok-Wing Tsui, Stephen Kwok-Wing Tsui, Stephen Kwok-Wing Tsui   +5 more
doaj   +1 more source