Results 51 to 60 of about 46,392 (251)

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]

open access: yes, 2014
Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf   +43 more
core   +2 more sources

Evaluation of the difference between mean corpuscular haemoglobin concentration and mean cellular haemoglobin concentration in canine complete blood count assessed with an automated haematology analyser

open access: yesJournal of Small Animal Practice, EarlyView.
Objectives The study aimed (a) to establish the reference interval for Δmean corpuscular haemoglobin concentration‐mean cellular haemoglobin concentration in healthy dogs by ADVIA 2120 haematology analyser, (b) to identify the causes of increased Δmean corpuscular haemoglobin concentration‐mean cellular haemoglobin concentration in both healthy and ...
M. G. Ferrari   +5 more
wiley   +1 more source

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]

open access: yes, 2016
Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA   +4 more
core   +7 more sources

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel   +5 more
wiley   +1 more source

Microbial symbionts : a resource for the management of insect-related problems [PDF]

open access: yes, 2011
Microorganisms establish with their animal hosts close interactions. They are involved in many aspects of the host life, physiology and evolution, including nutrition, reproduction, immune homeostasis, defence and speciation.
Alma, Alberto   +10 more
core   +2 more sources

A Simple Genotyping Method for Rapid Differentiation of Blastocystis Subtypes and Subtype Distribution of Blastocystis spp. in Thailand

open access: yesPathogens, 2019
Blastocystis spp. is one of the most common protozoa of humans and animals worldwide. The genetic diversity of Blastocystis spp. might be associated with a wide range of symptoms.
Nittaya Srichaipon   +4 more
doaj   +1 more source

Larvicidal Activity of Phytochemicals From Handroanthus impetiginosus Seeds Against Culex quinquefasciatus

open access: yesChemistry &Biodiversity, Volume 22, Issue 12, December 2025.
The hexane extract was obtained from the seeds of H. impetiginosus, from which fatty acids and FAMEs were obtained. The three samples were tested on C. quinquefasciatus larvae, promoting mortality with moderate LC50 values. The hexane extract was analyzed by gas chromatographymass spectrometry (GC‐MS), and the most abundant compounds were ethyl oleate (
Luana Cristina Diniz Santos   +6 more
wiley   +1 more source

Breast filariasis [PDF]

open access: yesJournal of Surgical Case Reports, 2014
Filarial involvement of breast is a rare entity. Here is an unusual case of an old lady with right breast lump with axillary lymphadenopathy mimicking breast carcinoma, cytologically diagnosed as filarial mastitis. The patient subsequently received antihelmenthic therapy and showed marked clinical response within few weeks.
Thakur, Mohim, Lhamo, Yangshen
openaire   +2 more sources

Historical and Projected Impact of Global Climate Change on the Extrinsic Incubation of Dirofilaria immitis

open access: yesEcology and Evolution, Volume 15, Issue 12, December 2025.
We have used past temperature records and future temperature projections to understand the past and possible future epidemiology of canine heartworm. The range of the area hyperendemic for heartworm may change in the future, especially in extreme carbon emissions scenarios.
Peter Jonathon Atkinson   +2 more
wiley   +1 more source

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