Results 101 to 110 of about 284,225 (286)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

File Fragment Analysis Using Normalized Compression Distance [PDF]

, 2013
The first step when recovering deleted files using file carving is to identify the file type of a block, also called file fragment analysis. Several researchers have demonstrated the applicability of Kolmogorov complexity methods such as the normalized compression distance (NCD) to this problem.
Axelsson, Stefan, Bajwa, Kamran, Srikanth, Mandhapati   +2 more
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Global Dataset Mapping the AI Innovation from Academic Research to Industrial Patents

Scientific Data
In the rapidly evolving field of artificial intelligence (AI), mapping innovation patterns and understanding effective technology transfer from research to applications are essential for economic growth. However, existing data infrastructures suffer from
Haixing Gong, Hui Zou, Xingzhou Liang, Shiyuan Meng, Pinlong Cai, Xingcheng Xu, Jingjing Qu   +6 more
doaj   +1 more source

Reconstructing Fragmented YAFFS2 Files for Forensic Analysis

International Journal of Hybrid Information Technology, 2015
Data recovery from captured intelligent mobile devices such as smartphones plays a significant role in digital forensic analysis. In this paper, we study the main characteristics of NAND flash and YAFFS2 file systems and explore the method for recovering YAFFS2 files for forensic analysis based on Tnode tree that can save a lot of time compared to ...
Na Huang, Jingsha He, Bin Zhao, Gongzheng Liu, Xuejiao Wan   +4 more
openaire   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Application of a molecular networking approach using LC-HRMS combined with the MetWork webserver for clinical and forensic toxicology

Heliyon
Backgrounds and aims: In toxicology, LC-HRMS for untargeted screening yields a great deal of high quality spectral data. However, there we lack tools to visualize/organize the MS data.
Romain Magny, Yann Beauxis, Gregory Genta-Jouve, Emmanuel Bourgogne   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

File fragment encoding classification—An empirical approach

Digital Investigation, 2013
Over the past decade, a substantial effort has been put into developing methods to classify file fragments. Throughout, it has been an article of faith that data fragments, such as disk blocks, can be attributed to different file types. This work is an attempt to critically examine the underlying assumptions and compare them to empirically collected ...
Vassil Roussev, Candice Quates
openaire   +1 more source