Results 151 to 160 of about 284,225 (286)

Loss of mitochondrial single stranded DNA-binding protein (mtSSB) gene is associated with mitochondrial genome fragmentation in Psocodea (bark lice, book lice, and parasitic lice). [PDF]

BMC Biol
Song N, Shao R.
europepmc   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

96 sample parallel acoustic fragmentation for high throughput next generation sequencing library preparation. [PDF]

PLoS One
Mehrab-Mohseni M, Bautista KJB, Liu Y, Maldonado-Rosado EE, Zheng H, Niederhuber MJ, Rosen JD, Carroll MD, Velasco B, Tsuruta JK, Kim J, Marron JS, Haaland PD, Kasoji SK, Mieczkowski PA, Hepperla AJ, Dayton PA, Pattenden SG.   +17 more
europepmc   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment. [PDF]

Nat Commun
Zhu Y, Zheng S, Shao Y, Zhou J, Gu X, Shen L, Li X, Liu W, Xue W, Lu H, Zhou J, Ding J, Deng H, Chen J, Yu Z, Yao Y, Xia W, Chen W, Sun S, Wang Z, Qian T, Yu X, Liu J, Chen Y, Lin Z, Huang J, Ni C.   +26 more
europepmc   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

GelInsight: Open-source software for large-sample DNA fragmentation quality control in gel electrophoresis images. [PDF]

PLoS One
Bautista KJB, Mehrab-Mohseni M, Kiradoh SA, Dayton PA, Pattenden SG.   +4 more
europepmc   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Fragme∩t: An Open-Source Framework for Multiscale Quantum Chemistry Based on Fragmentation. [PDF]

Wiley Interdiscip Rev Comput Mol Sci
Broderick DR, Bowling PE, Brandt C, Childress S, Shockey J, Higley J, Dickerson H, Ahmed SS, Herbert JM.   +8 more
europepmc   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source