Results 81 to 90 of about 284,225 (286)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Galaxy QCxMS for straightforward semi-empirical quantum mechanical EI-MS prediction
GigaByteHigh-performance computing (HPC) environments are crucial for computational research, including quantum chemistry (QC), but pose challenges for non-expert users.
Wudmir Y. Rojas +5 more
doaj +1 more source
Feature‐based Type Identification of File Fragments [PDF]
Security and Communication Networks, 2012 AbstractDigital information is packed into files when it is going to be stored on storage media. Each computer file is associated with a type. Type detection of computer data is a building block in different applications of computer forensics and security. Traditional methods were based on file extensions and metadata.
Mehdi Chehel Amirani +2 more
openaire +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Universal Scaling Relations in Scale-Free Structure Formation [PDF]
, 2018 A large number of astronomical phenomena exhibit remarkably similar scaling relations. The most well-known of these is the mass distribution $\mathrm{d} N/\mathrm{d} M\propto M^{-2}$ which (to first order) describes stars, protostellar cores, clumps ...
Grudić, Michael Y. +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Circumstantial Evidence for a Critical Behavior in Peripheral Au + Au Collisions at 35 MeV/nucleon
, 1995 The fragmentation resulting from peripheral Au + Au collisions at an incident energy of E = 35 MeV/nucleon is investigated. A power-law charge distribution, $A^{-\tau}$ with $\tau \approx 2.2$, and an intermittency signal are observed for events selected
A. Bialas +70 more
core +1 more source
Comparison of Transfer-to-Continuum and Eikonal Models of Projectile Fragmentation Reactions [PDF]
, 2000 Spectroscopic properties of nuclei are accessible with projectile fragmentation reactions, but approximations made in the reaction theory can limit the accuracy of the determinations.
A. Bonaccorso +31 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Interference fragmentation functions and spin asymmetries
, 2001 A new class of fragmentation functions, arising from the interference of different hadron production channels, is analyzed. Their symmetry properties with respect to naive time-reversal transformations allow for the exploration of final-state ...
Radici, M.
core +2 more sources