Results 31 to 40 of about 289,055 (256)

File Fragment Classification-The Case for Specialized Approaches [PDF]

open access: yes2009 Fourth International IEEE Workshop on Systematic Approaches to Digital Forensic Engineering, 2009
Increasingly advances in file carving, memory analysis and network forensics requires the ability to identify the underlying type of a file given only a file fragment. Work to date on this problem has relied on identification of specific byte sequences in file headers and footers, and the use of statistical analysis and machine learning algorithms ...
Roussev, Vassil, Garfinkel, Simson
openaire   +2 more sources

RURAL TEACHER SERAFIMA KILINA: RECONSTRUCTION OF THE BIOGRAPHY OF "THE DEPRIVED WOMAN" OF THE 1930S.

open access: yesВестник Брянского государственного университета, 2021
The article is devoted to the analysis of the social situation of disenfranchised citizens. The object of the study is an ordinary citizen of the USSR: a former rural teacher and the wife of a priest Serafima Aleksandrovna Kilina (born in 1888), the ...
Kilin A.P.
doaj   +1 more source

Finding File Fragments in the Cloud [PDF]

open access: yes, 2012
As the use – and abuse – of cloud computing increases, it becomes necessary to conduct forensic analyses of cloud computing systems. This paper evaluates the feasibility of performing a digital forensic investigation on a cloud computing system. Specifically, experiments were conducted on the Nimbula on-site cloud operating system to determine if ...
Dirk Ras, Martin Olivier
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Predicting the types of file fragments

open access: yesDigital Investigation, 2008
A problem that arises in computer forensics is to determine the type of a file fragment. An extension to the file name indicating the type is stored in the disk directory, but when a file is deleted, the entry for the file in the directory may be overwritten.
William C. Calhoun, Drue Coles
openaire   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

EnCoD: Distinguishing Compressed and Encrypted File Fragments [PDF]

open access: yes, 2020
Reliable identification of encrypted file fragments is a requirement for several security applications, including ransomware detection, digital forensics, and traffic analysis. A popular approach consists of estimating high entropy as a proxy for randomness. However, many modern content types (e.g.
De Gaspari F.   +4 more
openaire   +4 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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