Results 51 to 60 of about 533,194 (286)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ITC-MNP: a diverse dataset for image file fragment classification

BMC Research Notes
Objectives Image file fragment classification is a critical area of study in digital forensics. However, many publicly available datasets in this field are derived from a single source, often lacking consideration of the diversity in image settings and ...
Behnam Tavassoli, Zhino Naghshbandi, Mehdi Teimouri   +2 more
doaj   +1 more source

File Fragment Type Classification Using Light-Weight Convolutional Neural Networks

IEEE Access
In digital forensics, file carving is used to extract files without relying on the underlying file system metadata. This process can be challenging if the file is fragmented. Therefore, it is important first to identify the type of file fragment.
Muhamad Felemban, Mustafa Ghaleb, Kunwar Saaim, Saleh AlSaleh, Ahmad Almulhem   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comparative evaluation of apical extrusion of intracanal bacteria using four single-file NiTi instruments: An in vitro study

Endodontology, 2019
Introduction: A major objective in root canal treatment is to clean the root canal system. During the process, dentine chips, pulp tissue fragments, necrotic tissue, microorganisms, and intracanal irrigants may be extruded through the apical foramen ...
A Sheerin Sarthaj, V Rajesh Gopal, A Arvind Kumar, Benin Paulaian, Lal Krishnan Raveendran, C S DeviPrasad   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparison of the centering ability of Wave·One and Reciproc nickel-titanium instruments in simulated curved canals

Restorative Dentistry & Endodontics, 2013
Objectives The aim of this study was to evaluate the shaping ability of newly marketed single-file instruments, Wave·One (Dentsply-Maillefer) and Reciproc (VDW GmbH), in terms of maintaining the original root canal configuration and curvature, with or ...
Young-Jun Lim, Su-Jung Park, Hyeon-Cheol Kim, Kyung-San Mi   +3 more
doaj   +1 more source

Waste management CDM projects barriers NVivo 10® qualitative dataset

Data in Brief, 2017
This article contains one NVivo 10® file with the complete 432 projects design documents (PDD) of seven waste management sector industries registered as Clean Development Mechanism (CDM) under United Nations Framework Convention on Climate Change ...
André Luiz Bufoni, Aracéli Cristina de Sousa Ferreira, Luciano Basto Oliveira   +2 more
doaj   +1 more source

Identification of fragmented JPEG files in the absence of file systems [PDF]

2015 IEEE Conference on Open Systems (ICOS), 2015
Identifying fragmented and deleted files from scattered digital storage become crucial needs in computer forensic. Storage media experience regular space fragmentation which gives direct consequence to the files system series. This paper specifies a case where the jpeg files are heavily fragmented with absent file header which contains maximum ...
Abdul Kadir, Nur Fasihah, Abd Razak, Shukor, Chizari, Hassan   +2 more
openaire   +1 more source