Results 31 to 40 of about 2,268,216 (242)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

EnCoD: Distinguishing Compressed and Encrypted File Fragments

, 2020
Reliable identification of encrypted file fragments is a requirement for several security applications, including ransomware detection, digital forensics, and traffic analysis.
De Gaspari F., Hitaj D., Mancini L. V., Pagnotta G., De Carli L.   +4 more
core   +2 more sources

ITC-MNP: a diverse dataset for image file fragment classification

BMC Research Notes
Objectives Image file fragment classification is a critical area of study in digital forensics. However, many publicly available datasets in this field are derived from a single source, often lacking consideration of the diversity in image settings and ...
Behnam Tavassoli, Zhino Naghshbandi, Mehdi Teimouri   +2 more
doaj   +1 more source

File Fragment Type Classification Using Light-Weight Convolutional Neural Networks

IEEE Access
In digital forensics, file carving is used to extract files without relying on the underlying file system metadata. This process can be challenging if the file is fragmented. Therefore, it is important first to identify the type of file fragment.
Muhamad Felemban, Mustafa Ghaleb, Kunwar Saaim, Saleh AlSaleh, Ahmad Almulhem   +4 more
doaj   +1 more source

TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach [PDF]

, 2009
Diaz NN, Krause L, Goesmann A, Niehaus K, Nattkemper TW. TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Naryttza N Diaz, Lutz Krause, Krause, Lutz, Niehaus Karsten, Diaz Naryttza N, Goesmann, Alexander ; https://orcid.org/, Goesmann Alexander, Niehaus, Karsten, Tim W Nattkemper, Goesmann, Alexander, Karsten Niehaus, Diaz, Naryttza N., Nattkemper, Tim W., Krause Lutz, Alexander Goesmann   +16 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficiency of fractured file retrieval according to different nickel-titanium alloys and fragment lengths

BMC Oral Health
Background The fracture of nickel-titanium (NiTi) rotary files may be considered a direct cause of endodontic treatment failure. This study aimed to evaluate the effect of alloy type and fragment length on the efficiency of fractured file removal under ...
Joon Hyuk Yoon, Yoshitsugu Terauchi, Jae-Hoon Kim, Sang Won Kwak, Hyeon-Cheol Kim   +4 more
doaj   +1 more source

Two-Stage Detect-Then-Classify Pipeline with DSAR-CNN for Robust Fragment Classification Under Padding and Bit-Flip Attacks

ITEGAM-JETIA
File fragment classification is fundamental to digital forensics and network security, enabling the recovery and identification of files when metadata is corrupted or absent. While state-of-the-art deep learning models on the FFT-75 benchmark achieve 65–
Teena Mary, Sreeja C S
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source