Results 61 to 70 of about 533,194 (286)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluating a File-Based Event Builder to enhance the Data Acquisition in the CMS Experiment [PDF]

EPJ Web of Conferences
The event builder in the Data Acquisition System (DAQ) of the CMS experiment at the CERN Large Hadron Collider (LHC) is responsible for assembling events at a rate of 100 kHz during the current LHC run 3, and up to750 kHz for the upcoming High Luminosity
Alawieh Jaafar, Arutjunjan Kareen, Bacharov Durasov Miguel, Behrens Ulf, Bocci Andrea, Branson James, Brummer Philipp Maximilian, Bugajski Jan Andrzej, Cano Eric, Cittolin Sergio, Corominas I Mariscot Albert, Darlea Georgiana-Lavinia, Deldicque Christian, Dobson Marc, Dvorak Antonin, Emmanouil Christos, Gaile Antra, Gigi Dominique, Glege Frank, Gomez-Ceballos Guillelmo, Gorniak Patrycja, Hegeman Jeroen, Izquierdo Moreno Guillermo, James Thomas Owen, Jayakumar Tejeswini, Karimeh Wassef, Krawczyk Rafał, Li Wei, Long Kenneth, Meijers Frans, Meschi Emilio, Morović Srećko, Odetayo Babatunde John, Orsini Luciano, Paus Christoph, Petrucci Andrea, Pieri Marco, Rabady Dinyar Sebastian, Racz Attila, Rizopoulos Theodoros, Sakulin Hannes, Schwick Christoph, Šimelevičius Dainius, Tzanis Polyneikis, Vazquez Velez Cristina, Žejdl Petr   +45 more
doaj   +1 more source

Repository-based plasmid design [PDF]

There was an explosion in the amount of commercially available DNA in sequence repositories over the last decade. The number of such plasmids increased from 12,000 to over 300,000 among three of the largest repositories: iGEM, Addgene, and DNASU.
Densmore, Doug, Timmons, Joshua J.
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Fragmentation patterns of forest and cerrado vegetation in northeastern Mato Grosso

Revista Agrogeoambiental, 2022
This study sought to evaluate the fragmentation patterns of the forest and cerrado vegetation in the northeast of the state of Mato Grosso. The investigation used landscape metrics after extracting those fragments from the shapefile of soil use and ...
Raphael Maia Aveiro Cessa, Uirá do Amaral, Felipe Gimenes Rodrigues Silva, Nilton Nélio Cometti   +3 more
doaj  

A computational method for estimating the PCR duplication rate in DNA and RNA-seq experiments. [PDF]

BackgroundPCR amplification is an important step in the preparation of DNA sequencing libraries prior to high-throughput sequencing. PCR amplification introduces redundant reads in the sequence data and estimating the PCR duplication rate is important to
Bansal, Vikas
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

The key security management scheme of cloud storage based on blockchain and digital twins

Journal of Cloud Computing: Advances, Systems and Applications
As a secure distributed ledger technology, blockchain has attracted widespread attention from academia and industry for its decentralization, immutability, and traceability characteristics.
Jie Huang, Jiangyi Yi
doaj   +1 more source