Results 61 to 70 of about 295,131 (255)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Multi-keyword partial matching algorithm based on text fragments
Tongxin xuebao, 2010 Network content detection based on Key words in security gateway often need to reassemble the TCP packets and even the whole file, which will cause a long delay.
LIAO Wei-qi, ZOU Wei
doaj +2 more sources
uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames.
PLoS ONE, 2019 Ribosome profiling (ribo-seq) provides a means to analyze active translation by determining ribosome occupancy in a transcriptome-wide manner. The vast majority of ribosome protected fragments (RPFs) resides within the protein-coding sequence of mRNAs ...
Anica Scholz +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Dentistry JournalBackground/Objectives: Instrument fracture remains a significant complication in endodontics. This study compared the resistance to cyclic fatigue failure between rotary and reciprocating nickel–titanium file systems, as well as differences related to ...
Sverre Brun +4 more
doaj +1 more source
Hierarchical Clustering of Large Databases and Classification of Antibiotics at High Noise Levels
Algorithms, 2008 A new algorithm for divisive hierarchical clustering of chemical compounds based on 2D structural fragments is suggested. The algorithm is deterministic, and given a random ordering of the input, will always give the same clustering and can process a ...
Alexander V. Yarkov, Sergei V. Trepalin
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
SIFT: Sifting file types—application of explainable artificial intelligence in cyber forensics
CybersecurityArtificial Intelligence (AI) is being applied to improve the efficiency of software systems used in various domains, especially in the health and forensic sciences.
Shahid Alam, Alper Kamil Demir
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Intraradicular Splinting with Endodontic Instrument of Horizontal Root Fracture
Case Reports in Dentistry, 2015 Introduction. Root fractures, defined as fractures involving dentine, cementum, and pulpal and supportive tissues, constitute only 0.5–7% of all dental injuries.
Ersan Çiçek +2 more
doaj +1 more source