Results 81 to 90 of about 529,627 (283)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Extracting text from PostScript [PDF]

, 1997
We show how to extract plain text from PostScript files. A textual scan is inadequate because PostScript interpreters can generate characters on the page that do not appear in the source file.
Nevill-Manning, Craig G., Reed, Todd, Witten, Ian H.   +2 more
core   +1 more source

DRAGON: Monte Carlo generator of particle production from a fragmented fireball in ultrarelativistic nuclear collisions

, 2009
A Monte Carlo generator of the final state of hadrons emitted from an ultrarelativistic nuclear collision is introduced. An important feature of the generator is a possible fragmentation of the fireball and emission of the hadrons from fragments.
Adams, Adcox, Adler, Allton, Aoki, Becattini, Boris Tomášik, Braun-Munzinger, Broniowski, Broniowski, Chomaz, Cleymans, Csanád, Csörgő, de Forcrand, Fodor, Kisiel, Kisiel, Li, Mishustin, Mishustin, Press, Retiére, Scavenius, Tomášik, Tomášik, Torrieri, Torrieri, Torrieri, Torrieri, Yao   +30 more
core   +1 more source

Digital representation of historical globes : methods to make 3D and pseudo-3D models of sixteenth century Mercator globes [PDF]

, 2012
In this paper, the construction of digital representations of a terrestrial and celestial globe will be discussed. Virtual digital (3D) models play an important role in recent research and publications on cultural heritage.
De Coene, Karen, De Maeyer, Philippe, De Wulf, Alain, Nuttens, Timothy, Ongena, Thérèse, Stal, Cornelis   +5 more
core   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Feature‐based Type Identification of File Fragments [PDF]

Security and Communication Networks, 2012
AbstractDigital information is packed into files when it is going to be stored on storage media. Each computer file is associated with a type. Type detection of computer data is a building block in different applications of computer forensics and security. Traditional methods were based on file extensions and metadata.
Mehdi Chehel Amirani, Mohsen Toorani, Sara Mihandoost   +2 more
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The key security management scheme of cloud storage based on blockchain and digital twins

Journal of Cloud Computing: Advances, Systems and Applications
As a secure distributed ledger technology, blockchain has attracted widespread attention from academia and industry for its decentralization, immutability, and traceability characteristics.
Jie Huang, Jiangyi Yi
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source