Results 91 to 100 of about 4,134,428 (339)

Design and Implementation of File Deduplication Framework on HDFS

open access: yesInternational Journal of Distributed Sensor Networks, 2014
File systems are designed to control how files are stored and retrieved. Without knowing the context and semantics of file contents, file systems often contain duplicate copies and result in redundant consumptions of storage space and network bandwidth ...
Ruey-Kai Sheu   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Large-scale File System Design and Architecture

open access: yesActa Polytechnica, 2002
This paper deals with design issues of a global file system, aiming to provide transparent data availability, security against loss and disclosure, and support for mobile and disconnected clients.First, the paper surveys general challenges and ...
V. Dynda, P. Rydlo
doaj  

Effective Discriminative Feature Selection with Non-trivial Solutions

open access: yes, 2015
Feature selection and feature transformation, the two main ways to reduce dimensionality, are often presented separately. In this paper, a feature selection method is proposed by combining the popular transformation based dimensionality reduction method ...
Hou, Chenping   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Exploring Forensic Implications of the Fusion Drive

open access: yesJournal of Digital Forensics, Security and Law, 2014
This paper explores the forensic implications of Apple's Fusion Drive. The Fusion Drive is an example of auto-tiered storage. It uses a combination of a flash drive and a magnetic drive.
Shruti Gupta, Marcus Rogers
doaj  

Evolutionary Game Theory-Based Evaluation of P2P File-Sharing Systems in Heterogeneous Environments

open access: yesInternational Journal of Digital Multimedia Broadcasting, 2010
Peer-to-Peer (P2P) file sharing is one of key technologies for achieving attractive P2P multimedia social networking. In P2P file-sharing systems, file availability is improved by cooperative users who cache and share files.
Yusuke Matsuda   +2 more
doaj   +1 more source

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