Results 91 to 100 of about 2,622 (185)

A case of rhupus treated with filgotinib: A promising therapeutic perspective [PDF]

Rhupus syndrome: Rhupus syndrome, characterized by overlapping clinical features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), presents significant therapeutic challenges due to its complex pathogenesis and limited treatment ...
Rella V., Paolo Cantatore F., Corrado A., Barile R., Rotondo C.   +4 more
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Process for the preparation of Filgotinib maleate [PDF]

The present invention relates to crystalline form of N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropane carboxamide, maleate of formula-1 referred to as Filgotinib maleate, which is represented by the ...
, MSN Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, KESHAVAREDDY, Navin Kumar Reddy, Dr. P. Raja Gopal, V.Dathatreya
core  

Real-world Cohort Study on the Effectiveness and Safety of Filgotinib Use in Ulcerative Colitis [PDF]

BACKGROUND: Filgotinib is a small molecule with preferential inhibition of Janus kinase type 1, approved for the treatment of ulcerative colitis in Scotland in May 2022. We present the first real-world experience on its use in clinical practice. METHODS:
Goodall, M, Plevris, N, O’Hare, C, Gros, B, Constantine-Cooke, N, Jones, GR, Arnott, ID, Elford, AT, Lees, CW, Noble, C   +9 more
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Interindividual variability and its impact on the effectiveness of Janus kinase inhibitors in rheumatoid arthritis treatment

Frontiers in Medicine
IntroductionAchieving the primary treat-to-target (T2T) goal in rheumatoid arthritis (RA) remains challenging for many patients, reflecting limitations in the effectiveness of existing treatments. Our study examines factors influencing Janus kinase (JAK)
Cristina Martinez-Molina, Cristina Martinez-Molina, Silvia Vidal, Silvia Vidal, Cesar Diaz-Torne, Cesar Diaz-Torne, Cesar Diaz-Torne, Hye S. Park, Hye S. Park, Hye S. Park, Hèctor Corominas, Hèctor Corominas, Hèctor Corominas   +12 more
doaj   +1 more source

Focus on Filgotinib in Rheumatoid Arthritis: A Trial-Based Review

Mediterranean Journal of Rheumatology
Janus kinases (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is involved in pathophysiologic cascade of a notable number of rheumatic diseases. The development of JAK inhibitors has expanded treatment choices in rheumatoid arthritis (RA) with a sustained class-effect efficacy.
Skouvaklidou, Elpida, Deligeorgakis, Dimitrios, Skalkou, Anastasia, Skepastianos, Vasileios, Tsafis, Konstantinos, Papadimitriou, Evdokia, Pagkopoulou, Eleni, Avgerou, Paraskevi, Mytilinaiou, Maria G, Tzitiridou-Chatzopoulou, Maria, Kougkas, Nikolaos, Adamichou, Christina   +11 more
openaire   +2 more sources

Experimental and Investigational Pharmacotherapy for Psoriatic Arthritis: Drugs of the Future

Journal of Experimental Pharmacology, 2020
Luca Navarini,1,* Damiano Currado,1,* Luisa Costa,2 Marco Tasso,2 Maria Sole Chimenti,3 Francesco Caso2 1Unit of Rheumatology, Immunology and Clinical Medicine, Università Campus Bio-Medico Di Roma, Rome, Italy; 2Rheumatology Unit, Department of ...
Navarini L, Currado D, Costa L, Tasso M, Chimenti MS, Caso F   +5 more
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Filgotinib in cutaneous lupus: is a negative positive? [PDF]

Rheumatology, 2021
Kathryn Connelly, Eric F Morand
openaire   +2 more sources

Distinct trajectories of symptomatic response in ulcerative colitis during filgotinib therapy: A post hoc analysis from the SELECTION study. [PDF]

peer reviewedBACKGROUND: Filgotinib is an oral, once-daily, Janus kinase 1 preferential inhibitor approved for treatment of ulcerative colitis (UC) following the phase 2b/3 SELECTION trial.
Feagan, Brian G, Harris, Kristina, Schreiber, Stefan, Hisamatsu, Tadakazu, Oortwijn, Alessandra, Dron, Louis, Hibi, Toshifumi, Jamoul, Corinne, Patel, Haridarshan, Peyrin-Biroulet, Laurent, Louis, Edouard, Taliadouros, Virginia   +11 more
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Refractory Pyostomatitis Vegetans With Multiple Aseptic Cutaneous Abscesses Successfully Treated With Filgotinib in Ulcerative Colitis

JEADV Clinical Practice
We report on a 31‐year‐old male patient diagnosed with active moderate‐to‐severe ulcerative colitis and a history of splenectomy. He was hospitalized due to confluent pustular oral lesions and multiple skin abscesses.
C. Dandoy, D. Franchimont, C. Delvaux, A. Buggenhout, D. Bernardi, V. Del Marmol, J. M. L. White   +6 more
doaj   +1 more source

Filgotinib [PDF]

, 2020
openaire   +1 more source