Results 41 to 50 of about 1,607 (262)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Enfances, Familles, Générations, 2015 This article takes up the line of thought arising out of bioethical research that seeks to analyze the intersection of three phenomena : the development of new assisted human reproduction technologies ; their legal and normative framework ; and new ...
Marta Roca i Escoda
doaj
Fratries amies, fratries ennemies dans La Mariane de Tristan
Etudes EpistémèThis article deals with the dramatic role of brothers and sisters in La Mariane, especially the symbolic function attributed to them. The playwright sets up a direct confrontation between two groups of contradictory characters: on the one hand, the ...
Sandrine Berrégard
doaj +1 more source
Interfaces: A Journal of Medieval European Literatures, 2015 The influence of King Alfonso X of Castile (reg. 1252–1284) has been so wide that modern historians have stressed Alfonso’s foundational role as a ‘father’ of many Castilian cultural institutions and areas of writing, including prose literature, science,
Ryan Szpiech
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Mnemosyne, 2018 La phrase fatidique du père du narrateur de L’Adoration (1965) rapportée dès l’incipit: «Il en a, un tarin!», maintes fois répétée par sa mère, orienta selon Jacques Borel toute sa vie affective. En 2003, son petit-fils Grégoire Hetzel, qui n’avait pas hérité de son nez mais du physique d’un père absent, raconte dans Le Vert Paradis qu’il faisait des ...
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Amphitryon d’Ignacio Padilla : échecs et crise de la filiation
Recherches, 2012 Je propose d’analyser le roman Amphitryon de l’écrivain mexicain Ignacio Padilla en interrogeant la relation mise en place entre le jeu d’échecs (dont l’enjeu est d’intervertir les identités des joueurs) et la crise de la filiation.
Emilie Etemad-Kasaeyan
doaj +1 more source
Filiation as a crossroads in Bahia
Anthropology Today, 2018 Drawing on ethnographic material collected in Bahia (Brazil) between 2004 and 2011, this article presents an alternative account of the notion of ‘filiation’ that avoids the equivoques concerning this concept that are dominant within contemporary anthropological discourses on kinship.
openaire +1 more source