Results 61 to 70 of about 1,607 (262)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
El retorno de lo contemporáneo: crisis e historicidad en El año del desierto de Pedro Mairal
Cuadernos LIRICO, 2019 This article examines Pedro Mairal’s El año del desierto through various theoretical approaches to the concept of the contemporary. In contrast to the novels of genealogy, this is a text that works with the remains of Argentine literature and goes back ...
Nicolás Campisi
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Géographie et CulturesSince 2002, it has been possible to bath in Copenhagen’s harbour. Popular among its inhabitants, bathing shows us a new relationship between people and their city, where waterfront areas allow the inhabitants to relax and expose their bodies to the sun ...
Clément Brun
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Enfances, Familles, Générations, 2018 Research Framework: Every year in Quebec, thousands of children are supported by the Child Welfare Program following the endangerment of their safety or development.
Ariane Boyer, Raphaële Noël
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Quand Minette rentre dans la parenté
Enfances, Familles, Générations, 2019 Research framework: Pet animals often have a central role in the family, and can be a facilitator within a structure based on filiations. A link is established between the evolution of the family structure in which the individuation of family members is ...
Sophie Michon-Chassaing +1 more
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L'Atelier du CRH, 2018 In an article published in 2015 (« La France profonde. Relations de parenté et alliances matrimoniales (xvie-xviiie siècle) », Annales HSS), Gérard Delille used the massive and dense material he had accumulated on matrimonial alliances over several ...
Sylvie Steinberg
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source