Results 61 to 70 of about 5,689,479 (302)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Study on optimization of expansion material ratio and filling effect of end slope mining tunnel

Meikuang Anquan
In order to solve the problem that the backfill body can not be connected to the roof in the process of end slope filling mining in open pit coal mine and to investigate the influence of filling rate on the deformation and failure characteristics of ...
Jingkai ZHU, Liu HAN, Jisen SHU, Zhaowan TAN, Tao CHEN   +4 more
doaj   +1 more source

ارزیابی تنش خشکی و محلول پاشی متانول بر مقدار پروتئین و روغن دانه، سرعت و دوره پر شدن دانه سویا ((L17 [PDF]

تنش های محیطی در علوم زراعی, 2010
به منظور بررسی اثر خشکی و متانول بر عملکرد دانه و مقدار پروتین و روغن دانه، سرعت، مدت و روند پر شدن دانه در سویا، آزمایشی بصورت فاکتوریل و درقالب طرح پایه بلوکهای کامل تصادفی در 3 تکرار در سال زراعی 1387 در مزرعه پژوهشی دانشگاه آزاد اسلامی کرج اجرا شد ...
مجتبی میرآخوری, فرزاد پاکنژاد, محمد رضا اردکانی, علیرضا پازکی, پریسا ناظری, محمد اسماعیل پور جهرمی   +5 more
doaj   +1 more source

Super Rice With High Sink Activities Has Superior Adaptability to Low Filling Stage Temperature

Frontiers in Plant Science, 2021
To investigate the differential responses of super rice grain filling to low filling stage temperature (LT) and the regulative effect of nitrogen panicle fertilizer (NPF), physiological and molecular experiments were conducted with two super rice ...
Congshan Xu, Congshan Xu, Congshan Xu, Fei Yang, Xinao Tang, Xinao Tang, Xinao Tang, Bo Lu, Bo Lu, Bo Lu, Ziyu Li, Ziyu Li, Ziyu Li, Zhenghui Liu, Zhenghui Liu, Zhenghui Liu, Zhenghui Liu, Yanfeng Ding, Yanfeng Ding, Yanfeng Ding, Yanfeng Ding, Chao Ding, Ganghua Li, Ganghua Li, Ganghua Li, Ganghua Li   +25 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Changes in grain-filling characteristics of single-cross maize hybrids released in China from 1964 to 2014

Journal of Integrative Agriculture, 2023
Grain filling is the physiological process for determining the obtainment of yield in cereal crops. The grain-filling characteristics of 50 maize brand hybrids released from 1964 to 2014 in China were assayed across multiple environments.
Xing GAO, Yong-xiang LI, Ming-tao YANG, Chun-hui LI, Yan-chun SONG, Tian-yu WANG, Yu LI, Yun-su SHI   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploiting Grain-Filling Rate and Effective Grain-Filling Duration to Improve Grain Yield of Early-Maturing Maize [PDF]

, 2013
Early-maturing maize (Zea mays L.) genotypes yield 15 to 30% less than late-maturing genotypes. One strategy for improving grain yield in the early-maturing group involves assessment of grain-filling traits as secondary traits for selection for high ...
Tarekegne, A, Edema, R, Patrick Okori, Setimela, P, Richard Edema, Gasura, E, Gibson, P T, Amsal Tarekegne, Peter Setimela, Okori, P, Edmore Gasura, Paul T. Gibson   +11 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source