Results 121 to 130 of about 35,622 (198)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking

, 2011
Rab GTPases including Rab27a, Rab38 and Rab32 function in melanosome maturation or trafficking in melanocytes. A screen to identify additional Rabs involved in these processes revealed the localization of GFP-Rab17 on recycling endosomes (REs) and ...
Jennifer L. Stow, Norihiko Ohbayashi, Ryo Misaki, Moores, Matthew T., Cook, Anthony L., Misaki, Ryo, Kimberley A. Beaumont, Fukuda, Mitsunori, Oliver Cairncross, Nicholas A. Hamilton, Mitsunori Fukuda, Stow, Jennifer L., Hamilton, Nicholas A., Beaumont, Kimberley A., Anthony L. Cook, Matthew T. Moores, Taguchi, Tomohiko, Tomohiko Taguchi, Smith, Aaron G., Richard A. Sturm, Aaron G. Smith, Ohbayashi, Norihiko, Darren L. Brown, Brown, Darren L., Sturm, Richard A., Cairncross, Oliver   +25 more
core   +1 more source

The Role of Dendritic Spines in Water Exchange Measurements With Diffusion MRI: Time‐Dependent Single Diffusion Encoding MRI

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Geometric exchange between dendritic spines and shafts is often neglected, yet it exhibits the same signature as permeative exchange, biasing NEXI/SMEX measurements. We propose two models: an extended three‐compartment Kärger model that resolves spine–shaft exchange explicitly, and a coarse‐grained Kärger model that absorbs spines into an effective ...
Kadir Şimşek, Arthur Chakwizira, Markus Nilsson, Marco Palombo   +3 more
wiley   +1 more source

Co‐Optimization of Mechanical Performance and Osseointegration of Titanium‐Based Composites via a Novel Microwave‐Driven Boronization Strategy

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT The use of Ti6Al4V alloy in dental implantation is constrained by its high elastic modulus and biological inertness, which lead to delayed osseointegration and a high failure risk. Additionally, its chemical incompatibility with hydroxyapatite (HA) impedes the development of stable bioactive composites.
Shangyong Zuo, Hengrong Xiong, Xiaojie Chen, Yihong Chen, Xiupeng Zhu, Boyu Liu, Zhiwei Peng, Ailiang Chen, Qian Peng   +8 more
wiley   +1 more source

Self-Assembly of Filopodia-Like Structures on Supported Lipid Bilayers

, 2010
Pointing the Finger Filopodia are finger-like structures containing parallel bundles of actin filaments that are central to eukaryotic cell motility in a variety of contexts. K. Lee et al.
Kwonmoo Lee, Jennifer L. Gallop, Marc W. Kirschner, Komal Rambani   +3 more
core   +1 more source

Piezoelectric Nanofibrous Scaffolds for Promoting the Growth of Spiral Ganglion Neurons via Acoustic Stimulation

Smart Medicine, Volume 5, Issue 5, October 2026.
The piezoelectric nanofibrous scaffolds containing PANI, PLLA and Gelatin exhibited biomimetic structure, components, and piezoelectricity. Benefiting from the oriented nanofibers and electrical stimulation induced by wireless acoustic excitation, the SGNs cultured on the scaffolds showed enhanced neurite alignment, extension, and growth cone ...
Dongyu Xu, Cuntu Cheng, Shan Xu, Chuan Bu, Shuangba He, Sizhe Song, Yu Wang, Busheng Tong, Yangnan Hu, Huan Wang, Renjie Chai   +10 more
wiley   +1 more source

Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions

European Journal of Neuroscience, Volume 64, Issue 7, October 2026.
Oligodendrocyte progenitor cells (OPCs) are increasingly recognised as multifunctional CNS cells rather than mere precursors of myelinating oligodendrocytes. Alongside myelination and remyelination, they contribute to myelin and circuit plasticity, circuit regulation, vascular and blood–brain barrier regulation and neuroimmune modulation.
Alerie G. de la Fuente
wiley   +1 more source

Structures in focus--filopodia

, 2002
Filopodia are thin cell surface extensions filled with tight parallel bundles of actin filaments. They are highly dynamic structures which rapidly extend and retract as well as sweep up and down and from side to side, and can be found at the leading edge
Martin, Paul, Wood, Will J, Wood, William   +2 more
core  

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source