Results 201 to 210 of about 4,190,276 (347)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Artifact-free ultralow-temperature DNP-enhanced NMR of molecular assemblies at natural isotopic abundance. [PDF]

Sci Adv
Reynard-Feytis Q, Paul S, Hediger S, De Paëpe G.   +3 more
europepmc   +1 more source

Mapping the functional connectome of the claustrum: Noise filtering via local inhibitory circuits [PDF]

Martin Graf, Sadra Sadeh, George J. Augustine   +2 more
openalex   +1 more source

Filterable Viruses [PDF]

The Veterinary Journal (1900), 1929
openaire   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Ill-posed analysis of time-domain deconvolution identification of ice load on the shell structures of ice-going vessels. [PDF]

Sci Rep
Kong S, Lei J.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Plasmonic filter paper for microplastic detection: SERS enhancement, size dependence, and quantitative limitations. [PDF]

RSC Adv
Kim M, Lee D, Shin DW, Lee S, Chung CH, Wi JS.   +5 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Electroporation of Whole-Mount Postnatal Rodent Retinas for Advanced Functional Assays. [PDF]

Bio Protoc
Huang CT, Chen TJ, Su YL, Tseng CC, Chen PC, Wang CT.   +5 more
europepmc   +1 more source