Results 91 to 100 of about 286,663 (267)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
NONLINEAR AVERAGING FILTER WITH HYPERBOLIC WEIGHTS
Вестник Кемеровского государственного университета, 2013 The algorithm of a digital averaging filter, using hyperbolic weightsfor input values of the signal, is suggested. The results of digital modeling of the given filter are shown when processing monochrome images.
V. A. Tolstunov, Yu. V. Shlyndova
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
A New Analog Filter for Piezoelectric Sensors Signal Processing Designed for High Speed Weigh in Motion System [PDF]
, 2021 Lhoussaine Oubrich +2 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Signal Processing of Control and Protection for Traction ConverterBased on Butterworth Filter
机车电传动, 2016 Aiming at the problems of electric locomotive traction converters affected by the bad application environment andthe control strategy, which brought high frequency harmonic for sampling signal of control and protection and affected the controlperformance
ZHENG Yong, HUANG Qing, LI Xueming
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Journal of Ocean Engineering and ScienceA Two-Dimensional Convolutional Neural Network (2D-CNN)-based multi-feature fusion detection method is proposed to improve the detection performance of the submarine wake magnetic anomaly in view of its characteristics of low frequency and low signal-to ...
Ran Hui +3 more
doaj +1 more source
Second Order Low Pass RC Active Filter for Low Frequency Signal Processing
, 2020 Raj K. Tiwari +35 more
openalex +1 more source