Results 101 to 110 of about 2,461,002 (382)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Detecting Network Intrusions Using Signal Processing with Query-Based Sampling Filter

open access: yesEURASIP Journal on Advances in Signal Processing, 2008
This paper presents a novel approach for training a network intrusion detection system based on a query-based sampling (QBS) filter. The proposed QBS filter applies the concepts of data quantization to signal processing in order to develop a novel ...
Jen-Shiang Kouh   +2 more
doaj   +1 more source

Monaural Singing Voice Separation with Skip-Filtering Connections and Recurrent Inference of Time-Frequency Mask

open access: yes, 2017
Singing voice separation based on deep learning relies on the usage of time-frequency masking. In many cases the masking process is not a learnable function or is not encapsulated into the deep learning optimization.
Bengio, Yoshua   +5 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Preconditioning Filter Bank Decomposition Using Structured Normalized Tight Frames

open access: yesJournal of Applied Mathematics, 2015
We turn a given filter bank into a filtering scheme that provides perfect reconstruction, synthesis is the adjoint of the analysis part (so-called unitary filter banks), all filters have equal norm, and the essential features of the original filter bank ...
Martin Ehler
doaj   +1 more source

Advanced study of video signal processing in low signal to noise environments Semiannual progress report, Jun. - Nov. 1970 [PDF]

open access: yes
Video signal processing in low signal to noise environments - bandpass filter in multi-filter phase lock ...
Bowden, R., Carden, F.
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Beamforming Techniques for Multichannel audio Signal Separation

open access: yes, 2012
Beamforming is a signal processing technique. It has been studied in many areas such as radar, sonar, seismology and wireless communications, to name but a few.
Adel, Hidri   +3 more
core   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

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