Results 121 to 130 of about 247,844 (268)
IDEOLOG: A Program for Filtering Econometric Data - A Synopsis of Alternative Methods [PDF]
An account is given of various filtering procedures that have been implemented in a computer program, which can be used in analysing econometric time series.
D.S.G. Pollock
core
A model for mobile content filtering on non-interactive recommendation systems
, 2011 To overcome the problem of information overloading in mobile communication, a recommendation system can be used to help mobile device users. However, there are problems relating to sparsity of information from a first-time user in regard to initial ...
Wong, K.W. +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Learning Email Filtering Rules with Magi - A Mail Agent Interface
, 1994 As the volume of data on the Internet increases the need for better tools to handle this flood of data is also growing. Interface agents are tools which are designed to aid the user in using various applications. This project describes the development of
Payne, T.R.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2010 Recommender systems apply machine learning and data mining techniques for filtering unseen information and can predict whether a user would like a given resource.
Prugel-Bennett, Adam +1 more
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Ecosphere, 2018 Large‐scale environmental gradients have been invaluable for unraveling the processes shaping the evolution and maintenance of biodiversity. Environmental gradients provide a natural setting to test theories about species diversity and distributions ...
Stephanie Shooner +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Support in R for state space estimation via Kalman filtering was limited to one package, until fairly recently. In the last five years, the situation has changed with no less than four additional packages offering general implementations of the Kalman ...
Fernando Tusell
core