Results 61 to 70 of about 1,628,238 (276)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Effects of Filter’s Class, Cutoff Frequencies, and Independent Component Analysis on the Amplitude of Somatosensory Evoked Potentials Recorded from Healthy Volunteers

Sensors, 2019
Objective: The aim of this study was to investigate the effects of different preprocessing parameters on the amplitude of median nerve somatosensory evoked potentials (SEPs).
Muhammad Samran Navid, Imran Khan Niazi, Dina Lelic, Asbjørn Mohr Drewes, Heidi Haavik   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Filtering Capability of Porous Pavements

Proceedings, 2017
The objective of this study is to assess the filtering capability of porous pavement models and the quality of rainwater and stormwater filtered by such models.
Liseane Padilha Thives, Enedir Ghisi, Douglas G. Brecht, Dario M. Pires   +3 more
doaj   +1 more source

Evidence of Spin-Filtering in Quantum Constrictions with Spin-Orbit Interaction

, 2011
A new type of blockade effect - spin-orbit blockade (SOB) - is found in the conduction of a quantum dot (QD) made of a material with spin-orbit interaction.
Aharony A., Aikawa H., Akera H., Awschalom D. D., Costi T. A., Debray P., Entin-Wohlman O., Eto M., Goldhaber-Gordon D., Kouwenhoven L. P., Ono K., Silvestrov P. G., Van der Wiel W. G., Wan J., Winkler R., Yacoby A., Yamamoto M.   +16 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Case report: Rethinking NGS analysis in diagnosing Diamond-Blackfan anemia syndrome

Frontiers in Genetics
Diamond-Blackfan anemia syndrome (DBAS) is a rare inherited bone marrow failure (BMF) syndrome characterized by erythroid aplasia, congenital malformations, and cancer predisposition.
Panayiota L. Papasavva, Konstantinos Kaouranis, Stefania Byrou, Constantina G. Constantinou, Iacovou Efrosini, Marina Kleanthous, Carsten W. Lederer, Thessalia Papasavva   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High-order Radio Frequency Differentiation via Photonic Signal Processing with an Integrated Micro-resonator Kerr Optical Frequency Comb Source

, 2017
We demonstrate the use of integrated micro-resonator based optical frequency comb sources as the basis for transversal filtering functions for microwave and radio frequency photonic filtering and advanced functions.Comment: 8 pages, 7 figures, 46 ...
Chu, Sai T., Little, Brent E., Mitchell, Arnan, Morandotti, Roberto, Moss, David J., Shoeiby, Mehrdad, Wu, Jiayang, Xu, Xingyuan   +7 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source