Results 111 to 120 of about 157,436 (316)

Comportamento estocástico do algoritmo kernel least-mean-square [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Algoritmos baseados em kernel têm-se tornado populares no processamento não-linear de sinais.
Parreira, Wemerson Delcio
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Advances in crosshole seismic reflection processing [PDF]

, 1993
In recent years there have been significant advances in the acquisition and processing of crosshole seismic reflection data, and the method has been shown to be a high resolution imaging technique.
Rowbotham, Peter S
core  

Accurate Changing Point Detection for l(1) Mean Filtering

, 2016
It is often desirable to find the underlying trends in time series data. This is a well known signal processing problem that has many applications in areas such as financial data analysis, climatology, biological and medical sciences.
Ottersten, Johan,, Rojas, Cristian R.,, Wahlberg, Bo,   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Effect of Cut-Off Frequency on Signal Features When Filtering Equine sEMG Signal from Selected Extensor Muscles

Applied Sciences
The use of surface electromyography (sEMG) in equine locomotion research has increased significantly due to the essential role of balanced, symmetrical, and efficient movement in riding. However, variations in sEMG signal processing for forelimb extensor
Małgorzata Domino, Marta Borowska, Elżbieta Stefanik, Natalia Domańska-Kruppa, Bernard Turek   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

DYNAMIC ESTIMATION FOR PARAMETERS OF INTERFERENCE SIGNALS BY THE SECOND ORDER EXTENDED KALMAN FILTERING [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2014
Data processing in the interferometer systems requires high-resolution and high-speed algorithms. Recurrence algorithms based on parametric representation of signals execute consequent processing of signal samples.
P. A. Ermolaev
doaj  

Hibadetektálás korszerű analitikus módszerei járműipari alkalmazásokkal = Advanced analytic methods to fault detection with application to vehicle systems

, 2009
1) A rendszer modelljének invertálásán alapuló detektálószűrők tulajdonságainak kutatása során kapott eredmények, ideértve elsősorban az inverz geometriai tulajdonságait és az inverz dinamika előállítására vonatkozó módszereket, lehetővé tették az ...
Edelmayer, András, Fazekas, Zoltán, Szabó, Zoltán, Nádai, László, Soumelidis, Alexandros   +4 more
core