Results 51 to 60 of about 1,444 (254)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Wideband filtering power dividers with/without notch band

Microwave and Optical Technology Letters
AbstractLow loss and compact wideband filtering power dividers (WB‐FPDs) with/without notch band are proposed. The WB‐FPDs are designed using wideband bandpass filter based on asymmetric stepped‐impedance resonator (SIR). Parallel coupled microstrip lines are used to create both wideband filtering characteristic and two additional transmission poles. A
Ali Kursad Gorur, Engin Dogan, Ceyhun Karpuz, Adnan Gorur   +3 more
openaire   +3 more sources

Wideband unequal filtering power divider with high power dividing ratio based on line‐inserted method

IET Microwaves, Antennas & Propagation, 2021
In this study, a type of wideband‐filtering power divider (FPD) with high power dividing ratio (PDR) is proposed based on the line‐inserted method. The proposed wideband FPD is implemented by inserting a quarter‐wave line in front of the conventional ...
Di Wang, Xin Guo, Wen Wu
doaj   +1 more source

Wideband electromagnetic interference filtering power divider with a wide stopband using the genetic algorithm

Frontiers in Physics, 2023
This paper proposes a new design of an electromagnetic interference wideband filtering power divider (FPD) with a wide stopband based on the genetic algorithm (GA). A set of data structures is constructed by describing the corresponding connection method
Zhou Dai, Zhou Dai, Wei Li, Wei Li, Chenxin Ma, Wenfei Zhang, Wanchun Tang   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Design of Ka-band thin film power divider based on multi-line gap coupling

Dianzi Jishu Yingyong
The traditional power divider structure is difficult to meet the requirements of high frequency and miniaturization of microwave systems due to obvious high-frequency crosstalk and large volume of impedance conversion lines.
Xu Muhua, Zhou Yujin, Li Shuaishuai, Gu Jiangchuan, Zhou Jun, Shen Ya   +5 more
doaj   +1 more source

Dual-Band Filtering Balanced-to-Unbalanced Impedance-Transforming Power Divider With High Frequency Ratio and Arbitrary Power Division

IEEE Access, 2018
This paper presents a novel dual-band filtering balanced-to-unbalanced impedance transforming out-of-phase power divider using a simple admittance inverter with an extreme high frequency ratio and arbitrary power division, which is composed of stepped ...
Zheng Zhuang, Yongle Wu, Mengdan Kong, Weimin Wang, Yuanan Liu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source