Results 111 to 120 of about 1,653,628 (289)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

3D Metal printed compact high‐Q bandpass filter using folded groove gap waveguide resonator with modified nails

Electronics Letters
This paper first presented a novel kind of modified curved nails for building the gap waveguide. By controlling the curved degrees, the realized gap waveguide can achieve a wider electromagnetic band gap range.
Zhuo‐Wei Miao, Ling Tian
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Strength of anisotropic nickel-mesh composite materials [PDF]

Metalurgija, 2008
The authors studied the characteristics of strength of filtering composite materials reinforced by a two-layer nickel mesh with a coating depending on the cutting-out angle.
Rudnitsky, N. P., Mamuzić, I.
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Reflected Group Delay of a Capacitively Coupled Resonator for Characterization of Dielectric Constant and Loss Tangent of Microstrip Substrates

IEEE Access
This paper presents a novel method to determine dielectric constant and loss tangent of substrates used in microstrip circuits. The method is based on the reflected group delay of a microstrip resonator coupled to the input by means of an interdigital ...
Gaurav Walia, Paul D. Laforge
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Continuous Wavelet Transform-Based Method for High-Sensitivity Detection of Image Signals of Fluorescence Lateral Flow Assay

Sensors
Fluorescence lateral flow assays (FLFA) based on quantum dot probes have attracted significant attention in recent years due to their high sensitivity and quantitative detection capabilities. FLFA requires the use of a straightforward fluorescence reader
Tao Zhang, Xiaosong Wu, Qian Wang, Long Zhang, Zhigang Li, Yangyang Peng, Qian Bian, Hui Shi, Yong Liu, Shu Wang   +9 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Meeting a need: development and validation of PubMed search filters for immigrant populations

Journal of the Medical Library Association
Objective: There is a need for additional comprehensive and validated filters to find relevant references more efficiently in the growing body of research on immigrant populations. Our goal was to create reliable search filters that direct librarians and
Q. Eileen Wafford, AHIP, Corinne H. Miller, Annie Wescott, Ramune K. Kubilius, AHIP   +3 more
doaj   +1 more source