Results 121 to 130 of about 718,563 (319)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Southern African Journal of Environmental EducationClimate Change Education (CCE) is widely recognised as one of the effective strategies for mitigating climate change challenges and risks. However, lack of the necessary knowledge and pedagogical skills among the majority of teachers in South Africa ...
Yvonne Nsubuga +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
fjmalmaraz/supervised-filters: Supervised Filters for EEG Signal.
, 2017 <p>This software reproduces calculations of standard power band filters (PBF) and DS filter, performed for the research paper" Supervised Filters for EEG Signal in Naturally Occurring Epilepsy Forecasting".
Francisco Javier Muñoz Almaraz +5 more
core +1 more source
Electronics LettersThis paper first presented a novel kind of modified curved nails for building the gap waveguide. By controlling the curved degrees, the realized gap waveguide can achieve a wider electromagnetic band gap range.
Zhuo‐Wei Miao, Ling Tian
doaj +1 more source
IEEE AccessThis paper presents a novel method to determine dielectric constant and loss tangent of substrates used in microstrip circuits. The method is based on the reflected group delay of a microstrip resonator coupled to the input by means of an interdigital ...
Gaurav Walia, Paul D. Laforge
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The planetary nebula population of M 33 as seen with J-PLUS photometry
Frontiers in Astronomy and Space SciencesIn this pilot study, we investigate the known PN population in M 33, a nearby spiral galaxy, at a distance of ≈840 kpc, using data from the DR3 of the Javalambre-Photometric Local Universe Survey (J-PLUS), a 12-band photometric dataset extensively used ...
G. Liberato +32 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source