Results 111 to 120 of about 1,669,726 (293)

Torque (Performance) Analysis, Exhaust Gas Emissions and Exhaust Flow Modeling Variation of Catalytic Converter Filter Number

Logic
In a combustion engine, to generate torque, a combustion and compression process is required. Apart from obtaining mechanical energy, the combustion results also produce exhaust emissions, which can result in a polluted environment. This research aims to
Hajar Isworo, Kurnia Dwi Artika, Muhammad Khalil, Imron Mustofa   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

3D Metal printed compact high‐Q bandpass filter using folded groove gap waveguide resonator with modified nails

Electronics Letters
This paper first presented a novel kind of modified curved nails for building the gap waveguide. By controlling the curved degrees, the realized gap waveguide can achieve a wider electromagnetic band gap range.
Zhuo‐Wei Miao, Ling Tian
doaj   +1 more source

Reflected Group Delay of a Capacitively Coupled Resonator for Characterization of Dielectric Constant and Loss Tangent of Microstrip Substrates

IEEE Access
This paper presents a novel method to determine dielectric constant and loss tangent of substrates used in microstrip circuits. The method is based on the reflected group delay of a microstrip resonator coupled to the input by means of an interdigital ...
Gaurav Walia, Paul D. Laforge
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Strength of anisotropic nickel-mesh composite materials [PDF]

Metalurgija, 2008
The authors studied the characteristics of strength of filtering composite materials reinforced by a two-layer nickel mesh with a coating depending on the cutting-out angle.
Rudnitsky, N. P., Mamuzić, I.
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring the Development of Teachers’ Personal Pedagogical Content Knowledge about Climate Change Education during a Continuing Teacher Professional Development Course

Southern African Journal of Environmental Education
Climate Change Education (CCE) is widely recognised as one of the effective strategies for mitigating climate change challenges and risks. However, lack of the necessary knowledge and pedagogical skills among the majority of teachers in South Africa ...
Yvonne Nsubuga, Ingrid Schudel, Zintle Songqwaru, Helen Fox   +3 more
doaj   +1 more source