Results 81 to 90 of about 22,951 (219)

Exploring the Development of Teachers’ Personal Pedagogical Content Knowledge about Climate Change Education during a Continuing Teacher Professional Development Course

Southern African Journal of Environmental Education
Climate Change Education (CCE) is widely recognised as one of the effective strategies for mitigating climate change challenges and risks. However, lack of the necessary knowledge and pedagogical skills among the majority of teachers in South Africa ...
Yvonne Nsubuga, Ingrid Schudel, Zintle Songqwaru, Helen Fox   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

3D Metal printed compact high‐Q bandpass filter using folded groove gap waveguide resonator with modified nails

Electronics Letters
This paper first presented a novel kind of modified curved nails for building the gap waveguide. By controlling the curved degrees, the realized gap waveguide can achieve a wider electromagnetic band gap range.
Zhuo‐Wei Miao, Ling Tian
doaj   +1 more source

Reflected Group Delay of a Capacitively Coupled Resonator for Characterization of Dielectric Constant and Loss Tangent of Microstrip Substrates

IEEE Access
This paper presents a novel method to determine dielectric constant and loss tangent of substrates used in microstrip circuits. The method is based on the reflected group delay of a microstrip resonator coupled to the input by means of an interdigital ...
Gaurav Walia, Paul D. Laforge
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The planetary nebula population of M 33 as seen with J-PLUS photometry

Frontiers in Astronomy and Space Sciences
In this pilot study, we investigate the known PN population in M 33, a nearby spiral galaxy, at a distance of ≈840 kpc, using data from the DR3 of the Javalambre-Photometric Local Universe Survey (J-PLUS), a 12-band photometric dataset extensively used ...
G. Liberato, D. R. Gonçalves, A. Cortesi, A. Cortesi, L. Lomelí-Núñez, A. Ederoclite, A. Ederoclite, Stavros Akras, L. A. Gutiérrez-Soto, L. A. Gutiérrez-Soto, V. Fragkou, M. Grossi, E. Telles, A. Alvarez-Candal, F. Jiménez-Esteban, A. J. Cenarro, A. J. Cenarro, D. Cristóbal-Hornillos, C. Hernández-Monteagudo, C. Hernández-Monteagudo, C. López-Sanjuan, C. López-Sanjuan, A. Marín-Franch, A. Marín-Franch, M. Moles, J. Varela, H. Vázquez Ramió, H. Vázquez Ramió, R. A. Dupke, R. A. Dupke, L. Sodré, R. E. Angulo, R. E. Angulo   +32 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source