Results 81 to 90 of about 290,900 (257)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
EnergiesThis study investigates the energy consumption and losses associated with the gas production process in a condensate gas reservoir-type gas storage system.
Hong Meng +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Combined depth and cake filtration coupled to flow simulation
, 2022 Paper L12-02, 11 S.Almost all theoretical studies on solid-liquid separation are either dedicated to depth filtration or cake filtration regimes, just a few are considering the case, when depth filtration is followed by cake filtration. At the same time,
Kirsch, R., Iliev, O., Osterroth, S.
core +1 more source
Time series denoising with wavelet transform
Journal of Telecommunications and Information Technology, 2005 This paper concerns the possibilities of applying wavelet analysis to discovering and reducing distortions occurring in time series.Wavelet analysis basics are briefly reviewed.
Bartosz Kozłowski
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cooling-tower-filtration-editorial-HydroChem-HVAC
, 2018 In February’s edition of HVAC&R Nation magazine HydroChem’s Roy McDougall discusses the design features present in a cooling-tower water-filtration ...
HydroChem Water Specialists (5854904)
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
, 2022 S.657-671Detailed computer simulations are a recent, efficient way to gain valuable insights into filter materials and particle filtration processes. The scales where filtration phenomena can be observed range from the macroscopic regime of flow around a
Cheng, L. +3 more
core +1 more source