Results 101 to 110 of about 763,836 (318)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Filtration Fields

open access: yes, 2009
Background In the international field of architectural design, sensing and tracking technologies are under-utilised in the creation of designerly, atmospheric environments, and are applied in the moderation of environmental comfort factors such as ...
Jakovich, J, McDermott, J
core  

Combined depth and cake filtration coupled to flow simulation

open access: yes, 2022
Paper L12-02, 11 S.Almost all theoretical studies on solid-liquid separation are either dedicated to depth filtration or cake filtration regimes, just a few are considering the case, when depth filtration is followed by cake filtration. At the same time,
Kirsch, R., Iliev, O., Osterroth, S.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

ANALYSIS OF INFLUENCE OF RUTIN AND GRAVITY ACTION ON THE RENAL EXCRETORY FUNCTION

open access: yesНаука и инновации в медицине, 2016
Aim - to analyze the effect of rutin on the renal excretory function in the conditions of normogravity and hypergravity. Materials and methods. 9 series of experiments were conducted, including 4 series with the use of a centrifuge of ultra-short radius.
E N Zaitceva, A V Dubishchev, V A Kurkin
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Optimising Ventilation Strategies for Improved Driving Range and Comfort in Electric Vehicles

open access: yesWorld Electric Vehicle Journal
A car cabin’s small volume makes it vulnerable to discomfort if temperature, humidity, and carbon dioxide levels are poorly regulated. In electric vehicles, the HVAC system draws energy from the car battery, reducing the driving range by several dozen ...
Matisse Lesage   +2 more
doaj   +1 more source

A COMPARISON OF DIFF ERENT RINSING METHODS UPON SELECTIVE DISSOLUTION OF IRON (OXY)HYDROXIDES IN SOILS/SEDIMENTS

open access: yesRudarsko-geološko-naftni Zbornik, 2017
Iron (oxy)hydroxides play an important role in a variety of disciplines, among others, environmental and exploration geochemistry, mineralogy, geology and soil science.
Marija Čambala   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A simple filtration technique for obtaining purified human chromosomes in suspension

open access: yesBioTechniques, 2014
Here we present a simple method for cleaning polyamine human mitotic chromosomes in solution. This was achieved by filtering intact (unburst) nuclei along with both large and small cytoplasmic debris through a series of different pore sized filters. Pure
Mohammed Yusuf   +3 more
doaj   +1 more source

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