Results 121 to 130 of about 763,836 (318)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
History and Development of Water Treatment for Human Consumption
HygieneThroughout history, humans have sought to drink water that is good for their health, according to the knowledge of the time. Hippocrates’ definition of water quality, “good water should be clear, light, aerated, without any perceptible odor or taste ...
Philippe Hartemann, Antoine Montiel
doaj +1 more source
Comparison of Robust Filtration Techniques in Geometrical Metrology
, 2012 Filtration is one of core elements of analysis tools in geometrical metrology. Filtration techniques are progressing along with the advancement of manufacturing technology.
Lou, Shan +4 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Screen filtration in seawater pretreatment: A pilot trial of the Forsta Filter
, 2012 This project set out to design, build and monitor a pilot trial of the self-cleaning ninety series Forsta Screen filter using polished seawater as the feedwater.
Ambrose, Michael
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Filtration of Bacteriophage [PDF]
Journal of Bacteriology, 1930 N W, Larkum, M F, Semmes
openaire +2 more sources
Dead-end and crossflow microfiltration of yeast and bentonite suspensions: experimental and modelling studies incorporating the use of artificial neural networks [PDF]
, 2008 The applicability of artificial neural networks (ANNs) and semi-empirical modelling techniques for correlation and prediction of the filtration characteristics of microfiltration systems was assessed.
Ní Mhurchú, Jenny
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source