Results 51 to 60 of about 4,004,190 (296)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Combined depth and cake filtration coupled to flow simulation

, 2022
Paper L12-02, 11 S.Almost all theoretical studies on solid-liquid separation are either dedicated to depth filtration or cake filtration regimes, just a few are considering the case, when depth filtration is followed by cake filtration. At the same time,
Kirsch, R., Iliev, O., Osterroth, S.
core   +1 more source

Analysis of Particulate and Microbiological Filtration Performance of Air Handling Unit Filters in a Low-Energy Office Building over 12 Months

Buildings, 2022
Indoor air quality is an important consideration for the health and well-being of building occupants, and the SARS CoV-2 pandemic highlighted the importance of maintaining proper ventilation in buildings.
Gaëtan Pavard, Aurélie Joubert, Yves Andrès, Pierre Le Cann   +3 more
doaj   +1 more source

Numerical simulation of colloidal dispersion filtration: description of critical flux and comparison with experimental results [PDF]

, 2006
During filtration via membrane processes, colloids accumulate at the porous surface leading to fouling phenomena. In this study, a rigorous simulation of momentum and mass transfer using CFD modelling has been developed to describe such an accumulation ...
Fletcher, David F., Bessiere, Yolaine, Bacchin, Patrice, Aimar, Pierre, Espinasse, Benjamin, Fletcher, David   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Filtration Analysis and Improvement of Ventilation and Cooling System on Auxiliary Transformer for HXD1 AC-drive Locmotive

机车电传动, 2012
The structure of the ventilation and cooling system of HXD1 locmotive auxiliary transformer was introduced.The filtrating principle of ventilation system was analyzed, the filtration efficiency of which was presented by test data.
邓木生, 钟福兵
doaj  

Design and Performance Evaluation of a Soybean Filtration Machine Utilizing an Electric Motor and Low-Torque Gearbox

Rekayasa
The traditional soybean filtration process in small- and medium-scale tofu industries remains inefficient due to labour-intensive operations, inconsistent extract quality, and high processing time. Manual pressing methods often result in reduced extract
Muhammad Affa Nur Fatta, Danang Dwi Saputro, Hanif Hidayat   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source