Results 81 to 90 of about 5,776,143 (257)

Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? [PDF]

, 2016
Creatinine, although widely used as a biomarker to measure renal function, has long been known as an insensitive marker of renal impairment. Patients with reduced renal function can have a creatinine level within the normal range, with a rapid rise when ...
Andrew Lunn
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Glomerular filtration rate in patients with gout and factors influencing the rate

Современная ревматология, 2007
Tsel' issledovaniya. Izuchenie fil'tratsionnoy sposobnosti pochek u bol'nykh podagroy i ee svyazi s klinicheskimi proyavleniyami zabolevaniya. Material i metody.
F M Kudaeva, A V Gordeev, V G Barskova, F M Kudayeva, A V Gordeyev, V G Barskova   +5 more
doaj   +3 more sources

A Letter to Editor Regarding Efficacy of Salivary Urea and Creatinine Compared to Serum Levels in Chronic Kidney Disease Patients: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Dear Editor, The article in your issue 2024 Jan; Vol 18(1): BC05-BC08, titled “Efficacy of Salivary Urea and Creatinine Compared to Serum Levels in Chronic Kidney Disease Patients: A Cross-sectional Study”.
Geeta Bhatia, Vaishali Dhat
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simulation d’une filtration liquide en canal poreux fermé à une extrémité avec prise en compte de la formation du dépôt [PDF]

, 2009
La formation d’un dépôt de filtration ainsi que les performances de filtration associées ont été étudiées par CFD en utilisant un maillage mobile.
CABASSUD, Corinne, SCHMITZ, Philippe, GUIGUI, Christelle, MENDRET, Julie   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Assessment of GFR by four methods in adults in Ashanti, Ghana : the need for an eGFR equation for lean African populations [PDF]

, 2010
Background. Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few. Methods.
Frank B. Micah, Banerjee, D, Miller, MA, Sally M. Kerry, Jacob Plange-rhule, Boa, Frances G., Cappuccio, Francesco, Kerry, Sally M., Kerry, SM, Frances G. Boa, Banerjee, Debashis, Sampson Antwi, Antwi, Sampson, John B. Eastwood, Antwi, S, Plange-Rhule , Jacob, Cappuccio, FP, Eastwood, John B., Emmett, L, Micah, FB, Debasish Banerjee, Plange-Rhule, J, Micah, Frank B., Boa, FG, Eastwood, JB   +24 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source