Results 101 to 110 of about 28,176 (313)

Fimbriae reprogram host gene expression – Divergent effects of P and type 1 fimbriae

open access: yesPLOS Pathogens, 2019
Pathogens rely on a complex virulence gene repertoire to successfully attack their hosts. We were therefore surprised to find that a single fimbrial gene reconstitution can return the virulence-attenuated commensal strain Escherichia coli 83972 to virulence, defined by a disease phenotype in human hosts. E.
Ines Ambite   +10 more
openaire   +5 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

open access: yesJournal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima   +3 more
wiley   +1 more source

Inflammation targets specific organs for cancer in carriers of BRCA1/2 pathway mutations [PDF]

open access: yes, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed.
Bernard Friedenson
core   +1 more source

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

open access: yes, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
Amaral   +51 more
core   +1 more source

Cooperative Roles for Fimbria and Filamentous Hemagglutinin in Bordetella Adherence and Immune Modulation

open access: yesmBio, 2015
Bordetella fimbriae (FIM) are generally considered to function as adhesins despite a lack of experimental evidence supporting this conclusion for Bordetella pertussis and evidence against a requirement for FIM in adherence of Bordetella bronchiseptica to
Erich V. Scheller   +3 more
semanticscholar   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

open access: yesJournal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis   +2 more
wiley   +1 more source

Molecular epidemiological analysis of Escherichia coli sequence type ST131 (O25:H4) and bla CTX-M-15among extended-spectrum-β- lactamase-producing E. coli from the United States, 2000 to 2009 [PDF]

open access: yes, 2012
Escherichia coli sequence type ST131 (from phylogenetic group B2), often carrying the extended-spectrum-β-lactamase (ESBL) gene bla , is an emerging globally disseminated pathogen that has received comparatively little attention in the United States ...
Ari Robicsek   +45 more
core   +1 more source

Antimicrobial Activity of Ultraviolet C Light as a Potential Novel Treatment for Moraxella bovis Infection—An In Vitro Study

open access: yesVeterinary Ophthalmology, EarlyView.
ABSTRACT Objective To investigate the antimicrobial effect of 275 nm wavelength ultraviolet C (UV‐C) light on M. bovis using an affordable, broadly available modified handheld device and to determine if photoreactivation plays a role in bacterial resistance to UV‐C. Methods UV‐C therapy (UVCT) was evaluated in vitro using triplicates of 3 M.
Bactelius Turicea   +4 more
wiley   +1 more source

Immunohistochemical analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity on the developmental dentate gyrus and hippocampal fimbria in fetal mice

open access: yesJournal of Veterinary Medical Science, 2015
Dioxins are widespread persistent environmental contaminants with adverse impacts on humans and experimental animals. Behavioral and cognitive functions are impaired by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. TCDD exerts its toxicity via the
Yoshihiro Kobayashi   +14 more
semanticscholar   +1 more source

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