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Formulation and characterisation of Bordetella pertussis fimbriae as novel carrier proteins for Hib conjugate vaccines

Vaccine, 2001
Haemophilus influenzae type b (Hib) capsular polysaccharide (polyribosylribitol phosphate, PRP) is the active component of conjugate vaccines that have proven successful in preventing invasive Hib disease. Conjugation of PRP to a protein carrier greatly improves its immunogenicity providing protection in infants and subsequent antibody maturation upon ...
Andrew Gorringe
exaly   +3 more sources

Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins

Microbes and Infection, 2005
Porphyromonas gingivalis is a predominant periodontal pathogen, whose fimbriae are considered to be a major virulence factor, especially for bacterial adherence and invasion of host cells. In the present study, we investigated the influence of fimbriae on the interactions between alphavbeta3- and alpha5beta1-integrins and their ligand extracellular ...
Ichiro Nakagawa   +2 more
exaly   +3 more sources

Fimbriae of Bacteroides nodosus: protein engineering of the structural subunit for the production of an exogenous peptide

"Protein Engineering, Design and Selection", 1989
The pattern of sequence variation between Bacteroides nodosus fimbrial subunits of different serotypes suggests a degree of flexibility, which might be exploited for protein engineering approaches for the expression of other peptides. We have tested this using the well-characterized peptide epitope from VP1 of foot-and-mouth disease virus (FMDV ...
Jennings, P. A.   +3 more
openaire   +4 more sources

Binding of Enterobacterial Fimbria to Proteins of Basement Membranes and Connective Tissue — A Novel Function for Fimbriae

1991
Fimbriae are important virulence factors in a number of enterobacterial infections. It is generally thought that they increase the pathogenic potential of bacteria by mediating adherence to glycoconjugates of host epithelia, thus giving resistance to mechanical clearance defense systems of the body.
Timo K. Korhonen   +10 more
openaire   +1 more source

Cloning and sequence analysis of the fimbriae associated protein (fap) gene fromActinobacillus actinomycetemcomitans

Microbial Pathogenesis, 1997
Fimbrial-associated protein, an attachment factor of Actinobacillus actinomycetemcomitans, was genetically analysed by cloning. The plasmid obtained was found to harbor a 1.7kb fragment which contained a 228bp open reading frame encoding 76 amino acids (7.970kDa).
K, Ishihara   +4 more
openaire   +2 more sources

Suppression of Salmonella enterica serovar Enteritidis excretion by intraocular vaccination with fimbriae proteins incorporated in liposomes

Developmental and Comparative Immunology, 2004
Liposome-associated fimbriae antigens (SEF14 and SEF21) were prepared for intraocular immunization to seek protective efficacy for intestinal infection with Salmonella enterica serovar Enteritidis. Chickens were immunized intraocularly with the antigens at 8 and 10 weeks of age.
Shinobu Watarai
exaly   +3 more sources

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