Synthesis of a Proposed Antigenic Hexapeptide from Escherichia Coli K88 Protein Fimbriae. [PDF]
Acta Chemica Scandinavica, 1986 The hexapeptide Boc-Asp-Asp-Tyr-Arg-Gln-Lys-OMe is assembled by stepwise synthesis in solution with an overall yield of 44%. N alpha-boc-amino acids, protected with benzyl or benzyloxycarbonyl groups in the side-chains, are coupled as active estes of 1-hydroxybenzotriazole in mixtures of dichloromethane and N,N-dimethylformamide.
Morten Meldal +6 more
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Efficacy of FimA antibody and clindamycin in silkworm larvae stimulated with Porphyromonas gulae
Journal of Oral Microbiology, 2021 Objective: Porphyromonas gulae, a major periodontal pathogen in animals, possesses fimbriae that have been classified into three genotypes (A, B, C) based on the diversity of fimA genes encoding fimbrillin protein (FimA). P.
Sho Yoshida +6 more
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Interactions of Streptococcus mutans Fimbria-Associated Surface Proteins with Salivary Components [PDF]
Clinical Diagnostic Laboratory Immunology, 1999 ABSTRACT Streptococcus mutans has been implicated as the major causative agent of human dental caries. S. mutans binds to saliva-coated tooth surfaces, and previous studies suggested that fimbriae may play a role in the initial bacterial adherence to salivary components.
C A, Ray +3 more
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Isolation and characterization of Bacteroides nodosus fimbriae: structural subunit and basal protein antigens [PDF]
Journal of Bacteriology, 1984 We examined the isolation of fimbriae from Bacteroides nodosus. It was found that the best preparations were obtained from the supernatant of washed cells cultured on solid medium, from which fimbriae could be recovered in high yield and purity by a simple one-step procedure.
J S, Mattick +3 more
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Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch. [PDF]
PLoS Genetics, 2018 The std locus of Salmonella enterica, an operon acquired by horizontal transfer, encodes fimbriae that permit adhesion to epithelial cells in the large intestine.
Lucía García-Pastor +4 more
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Synthesis of a Putative Antigenic Heptapeptide from Escherichia Coli K88 ab Protein Fimbriae. [PDF]
Acta Chemica Scandinavica, 1986 The heptapeptide Tyr-Arg-Glu-Asp-Met-Glu-Tyr-OMe, spanning region 213-219 of Escherichia coli K88 ab protein fimbriae, was synthesized with an overall yield of 37% using dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) preactivation in all condensation reactions. The C-terminal was protected as the methyl ester. The protection scheme of
Morten Meldal +6 more
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The Multifunctional Protein YdiV Represses P Fimbria-Mediated Adherence in Uropathogenic Escherichia coli [PDF]
Journal of Bacteriology, 2013 YdiV, a degenerate EAL domain protein, represses motility by interacting with FlhD to abolish FlhDC interaction with DNA. Here, we demonstrate that deletion of ydiV dysregulates coordinate control of motility and adherence by increasing adherence of Escherichia coli CFT073 to a bladder epithelial cell line by specifically increasing production of P ...
Rachel R, Spurbeck +3 more
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Duality of β-glucan microparticles: antigen carrier and immunostimulants [PDF]
, 2016 Designing efficient recombinant mucosal vaccines against enteric diseases is still a major challenge. Mucosal delivery of recombinant vaccines requires encapsulation in potent immunostimulatory particles to induce an efficient immune response. This paper
Baert, Kim +4 more
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Active sites of salivary proline-rich protein for binding to Porphyromonas gingivalis fimbriae [PDF]
Infection and Immunity, 1997 Porphyromonas gingivalis fimbriae specifically bind salivary acidic proline-rich protein 1 (PRP1) through protein-protein interactions. The binding domains of fimbrillin (a subunit of fimbriae) for PRP1 were analyzed previously (A. Amano, A. Sharma, J.-Y. Lee, H. T. Sojar, P. A. Raj, and R. J. Genco, Infect. Immun. 64:1631-1637, 1996).
K, Kataoka +5 more
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Structural and functional studies of Porphyromonas gingivalis fimbrial proteins
Journal of Oral Microbiology, 2017 Porphyromonas gingivalis expresses two forms of fimbriae, FimA and Mfa1. Each fimbria consists of five proteins; FimA-E and Mfa1-5. While the assembly of the type-1 fimbriae from Escherichia coli is well studied; the chaperone-usher pathway, very little ...
Karina Persson, Michael Hall
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