Results 61 to 70 of about 507,695 (247)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Review of funding for schooling: final report [PDF]
, 2012 Released to the public on 20 February 2012, this report on a review chaired by David Gonski, is the culmination of the first significant schools funding review since the Whitlam Government.
David Gonski
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2018 In this research, we zoom in on twenty local networks that are installed in the fight against child poverty of which nine are located in Flanders, eight in Wallonia and three in Brussels.
Jacquet, Nicolas
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Climate Change 2014 Synthesis Report [PDF]
, 2014 This Synthesis Report is based on the reports of the three Working Groups of the Intergovernmental Panel on Climate Change (IPCC), including relevant Special Reports.
Intergovernmental Panel on Climate Change
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Solar heating panel: Parks and Recreation Building, Saugatuck Township Park and Recreation Commission. Final report [PDF]
, 1980 This report is an account of the design and installation of a solar heating system on an existing building in Saugatuck, MI, using existing technology. The purpose of this program is to demonstrate the possibilities of alternative energy, educate local ...
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Incidence of Poor Health and Long-Term Care: Health Transitions in Europe – Results from the European Community Household Panel Survey and Institutional Data. ENEPRI Research Reports No. 34, 23 December 2006 [PDF]
, 2006 This is the final report of Work Package 3 of the AHEAD project, undertaken by the Personal Social Services Research Unit (PSSRU) at the University of Kent.
Shapiro, Judith., Bebbington, Andrew
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