Results 81 to 90 of about 507,695 (247)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Community EmPOWERment : final research report [PDF]
, 2004 This is the Final Research Report of the Community EmPOWERment project conducted by the Moreland Energy Foundation Limited (MEFL) and the Institute for Sustainable Futures (the Institute).
Erin Wilson (13069428) +3 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Other title: Transportation Finance Panel final report [PDF]
, 2016 "January 15, 2016.
Connecticut. Transportation Finance Panel,
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Assessing Risk of Harm to Children and Parents in Private Law Children Cases: Final Report [PDF]
, 2020 This is the final report of the expert panel appointed by the Ministry of Justice to assess how effectively the family courts identify and respond to allegations of domestic abuse and other serious offences, in cases involving disputes between parents ...
Trinder, Liz +5 more
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Development of surfaces optically suitable for flat solar panels. Final report [PDF]
, 1979 This final report contains three principal items. The first describes a simple and novel reflectometer which can separately evaluate the spectral and diffuse reflectivities of surfaces. A phase locked detection system for the reflectometer is also described.
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Design Guide for Precast UHPC Waffle Deck Panel System, including Connections, June 2013 [PDF]
, 2013 : As a part of an innovation project funded by the Federal Highway Administration (FHWA) Highways for LIFE program, a full-depth precast, ultra-high-performance concrete (UHPC) waffle deck panel and appropriate connections suitable for field ...
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Analysis and Optimization of Sandwich Panels. Final report.
, 2017 "The first part of this project, are general about sandwich structures. A sandwich construction, consist of two plate outsides (facings) glued to a core in the middle. Sandwiches are used in construction that must have a low weight, but a high stiffness. This indicated racing cars, aeroplane, ship shelters.
openaire +1 more source