Results 101 to 110 of about 507,695 (247)
Changing demand: flexibility of energy practices in households with children (final report) [PDF]
, 2015 This report summarises the findings and recommendations from the ‘Changing Demand: Flexibility of energy practices in households with children’ research project funded by the Consumer Advocacy Panel.
Yolande Strengers, Larissa Nicholls
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Final report on City Panel activities and recommendations
Report capturing the key discussions, outputs and recommendations of both City Panels.
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Blue Ribbon Panel on Water Sustainability final report [PDF]
, 2010 : This report analyzes 26 priority issues and makes 63 recommendations on how to improve and promote water recycling and conservation by the Arizona Department of Water Resources, Arizona Corporation Commission and Arizona Department of Environmental ...
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Media reviews: all sound and fury? [PDF]
, 2012 This report provides background on recent media reviews in Australia, and assesses what they may mean for the future. Since the seventeenth century the media have been seen as the watchdogs of democracy— guardians of the public interest, protecting the ...
Rhonda Jolly
core