Results 61 to 70 of about 2,690,910 (310)

Convolutions with probability densities and applications to PDEs

Electronic Journal of Differential Equations, 2017
In this article we introduce several new convolution operators, generated by some known probability densities. By using the inverse Fourier transform and taking inverse steps (in the analogues of the classical procedures used for example in the heat ...
Sorin G. Gal
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A modified Tikhonov regularization method for a class of inverse parabolic problems

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020
This paper deals with the problem of determining an unknown source and an unknown initial condition in a abstract final value parabolic problem. This problem is ill-posed in the sense that the solutions do not depend continuously on the data.
Saouli Nabil, Zouyed Fairouz
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

A Modified Multi-Step Crossover Fusion (MSXF) In Solving Some Deterministic Job Shop Scheduling Problem (JSSP) [TS157.5. M214 2008 f rb]. [PDF]

, 2008
This thesis addresses the job shop scheduling problem (JSSP) with the objective of minimising the makespan value. Tesis ini membincangkan masalah penskedulan kerja kedaian (JSSP) dengan objektif untuk meminimumkan masa ...
Omar, Mahanim
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Precise geoid computation using Stokes-Helmert's scheme and strict integrals of topographic effects

Geodesy and Geodynamics, 2019
The high-precision local geoid model was computed based on the improved Stokes-Helmert′s boundary value problem and strict integrals of topographic effects. This proposed method involves three steps.
Dongmei Guo, Huiyou He, Peng Sang
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Operational WKB solution to the initial/final-value problem for Beechem-Haas equations

Electronic Journal of Differential Equations, 2000
Operational and Wantzel-Kramers-Brillouin (WKB) methods are utilized to obtain an analytical approximate solution of the Beechem-Haas equation for the initial/final-value problem with system parameters of radial profile.
Valentino Anthony Simpao
doaj