Results 141 to 150 of about 139,236 (284)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Doctor Carlos Juan Finlay de Barres, paradigma en valores éticos profesionales
Correo Científico Médico, 2014 Roxana Finalés Hechavarría +1 more
doaj
[Clinical coordination and strengthening of primary care for cancer diagnosis in Latin America: a scoping reviewCoordenação clínica e fortalecimento da atenção primária no diagnóstico do câncer na América Latina: revisão de escopo]. [PDF]
Rev Panam Salud PublicaLuer-Aguila R +3 more
europepmc +1 more source
, 2010 Recently, the Appeal Committee of the Hong Kong Court of Final Appeal raised the question of whether that court had the power to hear an appeal against a decision of the Court of Appeal. The decision in question concerned a judgment of professional misconduct against an accountant by a disciplinary committee under the Professional Accountants Ordinance.
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
[As The Lancet Public Health says: Anyone can drown. No one should]. [PDF]
Aten PrimariaFernández-Guerrero IM.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2016 Se pregunta si los libros de notas finales requieren la firma para su ...
Gaitán Nieto, Liliana
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source