Results 61 to 70 of about 3,103,133 (269)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Unwanted loneliness in older adults: sociodemographic, economic and psychosocial determinants and self-reported loneliness-inducing situations

open access: yesBMC Public Health
Objective To analyse the factors associated with unwanted loneliness in non-institutionalized over-65-year-olds in Spain. Method A cross-sectional study was conducted on a representative national sample (n = 1,003) by means of computer-assisted telephone
Mª Elena Martínez-Ochoa   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Analysis of KPMG financial statements [PDF]

open access: yes, 2016
Analiza financijskih izvještaja (horizontalna, vertikalna, analiza financijskih pokazatelja te sustava pokazatelja) kvalitetna je osnovica i polazište planiranja budućeg poslovanja. Cilj ovog završnog rada je analizirati financijska izvješća društva KPMG
Bećirović, Samra
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Deep Learning for Financial Sentiment Analysis on Finance News Providers

open access: yes, 2016
Investors have always been interested in stock price forecasting. Since the development of electronic media, hundreds pieces of financial news are released on different media every day.
Chia-Chou Lee   +2 more
core   +1 more source

Theoretical Aspects on Measures of Directed Information with Simulations

open access: yesMathematics, 2020
Measures of directed information are obtained through classical measures of information by taking into account specific qualitative characteristics of each event.
Thomas Gkelsinis, Alex Karagrigoriou
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Financial analysis of Company Iran Argham

open access: yes, 2016
financial analysis of company Iran argham, describe the financial situation of a company headquartered in Tehran between years 2010-2015. also some recommendation in order to improve company's performance in future.BSc/BABusiness InformaticsN ...
Darabi, Shayan
core  

Semiotic analysis in financial markets

open access: yes, 2023
This chapter will provide an overview of the methods used for semiotic analysis, and steps researchers can use to validate their semiotic interpretation (e.g., triangulation). It will show how semiotic analysis can be used to evaluate the effect of socio-
Kim, A.
core  

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