Results 61 to 70 of about 5,863,144 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing and Combining Financial Conditions Indexes [PDF]

Finance and Economics Discussion Series, 2013
We evaluate the short horizon predictive ability of financial conditions indexes for stock returns and macroeconomic variables. We find reliable predictability only when the sample includes the 2008 financial crisis, and we argue that this result is driven by tailoring the indexes to the crisis and by non-synchronous trading.
Sirio Aramonte, Samuel Rosen, John W. Schindler   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fiscal Rules versus the Financial Condition of EU Local Government Units

Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2023
The financial crisis and significant deterioration of public finances have led to the strength- ening of instruments aimed at ensuring the financial stability of the state, including fiscal rules.
Elżbieta Malinowska-Misiąg
doaj  

A Tourism Financial Conditions Index [PDF]

, 2014
The paper uses monthly data on financial stock index returns, tourism stock sub-index returns, effective exchange rate returns and interest rate differences from April 2005 – August 2013 for Taiwan that applies Chang’s (2014) novel approach for constructing a tourism financial indicator, namely the Tourism Financial Conditions Index (TFCI). The TFCI is
Chang, C-L., Hsu, H-K., McAleer, M.
openaire   +6 more sources

THE EFFECT OF FINANCIAL INCLUSION ON THE PERFORMANCE OF MSMES IN NORTH SUMATERA WITH FINANCIAL LITERACY AS A MEDIATION [PDF]

This study aims to examine the effect of financial inclusion on the performance of Micro, Small, and Medium Enterprises (MSMEs), with financial literacy acting as a mediating variable.
Syaifuddin, Syaifuddin, Rosmaneliana, Dina, Siregar, Robert Tua, Aktar, Salim, Toni, Nagian   +4 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Анализ на финансовото състояние на земеделски стопанства в България

Икономика и управление на селското стопанство, 2013
Целта на настоящата статия е да се направи сравнителен анализ на финансовото състояние на наблюдавани стопанства в три региона на България за период от шест години. Изследваният период обхваща времето между 2006 и 2011 г.
СТАНИМИР АНДОНОВ
doaj  

IMPROVEMENT OF THE METHODS OF ROUTE SELECTION OF INNOVATIVE DEVELOPMENT OF AN ENTERPRISE ON THE BASIS OF THE ANALYSIS OF FINANCIAL AND STATISTICAL REPORTING

Статистика и экономика, 2016
An analysis of the indexes of the financial and innovation activity of industrial enterprises is given, six of them are identified. The methods of calculation of the indicators based on the financial and statistical reporting of enterprises is proposed ...
Irina A. Evseeva
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source